node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATL1 | BSCL2 | ENSBTAP00000019032 | ENSBTAP00000058695 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. | Seipin; Is a regulator of lipid catabolism essential for adipocyte differentiation. Necessary for correct lipid storage and lipid droplets maintenance; may play a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues. May also be involved in the central regulation of energy homeostasis (By similarity); Belongs to the seipin family. | 0.718 |
ATL1 | NIPA1 | ENSBTAP00000019032 | ENSBTAP00000002985 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. | NIPA magnesium transporter 1. | 0.770 |
ATL1 | REEP1 | ENSBTAP00000019032 | ENSBTAP00000064769 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. | Receptor expression-enhancing protein. | 0.957 |
ATL1 | SPART | ENSBTAP00000019032 | ENSBTAP00000010577 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. | Spartin; May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis. | 0.839 |
ATL1 | SPG21 | ENSBTAP00000019032 | ENSBTAP00000072725 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. | Maspardin; May play a role as a negative regulatory factor in CD4- dependent T-cell activation. | 0.579 |
ATL2 | BSCL2 | ENSBTAP00000058768 | ENSBTAP00000058695 | Atlastin GTPase 2. | Seipin; Is a regulator of lipid catabolism essential for adipocyte differentiation. Necessary for correct lipid storage and lipid droplets maintenance; may play a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues. May also be involved in the central regulation of energy homeostasis (By similarity); Belongs to the seipin family. | 0.479 |
ATL2 | NIPA1 | ENSBTAP00000058768 | ENSBTAP00000002985 | Atlastin GTPase 2. | NIPA magnesium transporter 1. | 0.607 |
ATL2 | REEP1 | ENSBTAP00000058768 | ENSBTAP00000064769 | Atlastin GTPase 2. | Receptor expression-enhancing protein. | 0.817 |
ATL2 | SPART | ENSBTAP00000058768 | ENSBTAP00000010577 | Atlastin GTPase 2. | Spartin; May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis. | 0.694 |
BSCL2 | ATL1 | ENSBTAP00000058695 | ENSBTAP00000019032 | Seipin; Is a regulator of lipid catabolism essential for adipocyte differentiation. Necessary for correct lipid storage and lipid droplets maintenance; may play a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues. May also be involved in the central regulation of energy homeostasis (By similarity); Belongs to the seipin family. | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. | 0.718 |
BSCL2 | ATL2 | ENSBTAP00000058695 | ENSBTAP00000058768 | Seipin; Is a regulator of lipid catabolism essential for adipocyte differentiation. Necessary for correct lipid storage and lipid droplets maintenance; may play a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues. May also be involved in the central regulation of energy homeostasis (By similarity); Belongs to the seipin family. | Atlastin GTPase 2. | 0.479 |
BSCL2 | NIPA1 | ENSBTAP00000058695 | ENSBTAP00000002985 | Seipin; Is a regulator of lipid catabolism essential for adipocyte differentiation. Necessary for correct lipid storage and lipid droplets maintenance; may play a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues. May also be involved in the central regulation of energy homeostasis (By similarity); Belongs to the seipin family. | NIPA magnesium transporter 1. | 0.642 |
BSCL2 | REEP1 | ENSBTAP00000058695 | ENSBTAP00000064769 | Seipin; Is a regulator of lipid catabolism essential for adipocyte differentiation. Necessary for correct lipid storage and lipid droplets maintenance; may play a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues. May also be involved in the central regulation of energy homeostasis (By similarity); Belongs to the seipin family. | Receptor expression-enhancing protein. | 0.724 |
BSCL2 | SPART | ENSBTAP00000058695 | ENSBTAP00000010577 | Seipin; Is a regulator of lipid catabolism essential for adipocyte differentiation. Necessary for correct lipid storage and lipid droplets maintenance; may play a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues. May also be involved in the central regulation of energy homeostasis (By similarity); Belongs to the seipin family. | Spartin; May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis. | 0.833 |
IST1 | MITD1 | ENSBTAP00000032246 | ENSBTAP00000005179 | IST1 homolog; ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Regulates early endosomal tubulation together wi [...] | Microtubule interacting and trafficking domain containing 1. | 0.763 |
IST1 | SPART | ENSBTAP00000032246 | ENSBTAP00000010577 | IST1 homolog; ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Regulates early endosomal tubulation together wi [...] | Spartin; May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis. | 0.864 |
ITCH | SPART | ENSBTAP00000000397 | ENSBTAP00000010577 | E3 ubiquitin-protein ligase. | Spartin; May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis. | 0.680 |
ITCH | WWP1 | ENSBTAP00000000397 | ENSBTAP00000020867 | E3 ubiquitin-protein ligase. | E3 ubiquitin-protein ligase. | 0.792 |
MITD1 | IST1 | ENSBTAP00000005179 | ENSBTAP00000032246 | Microtubule interacting and trafficking domain containing 1. | IST1 homolog; ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Regulates early endosomal tubulation together wi [...] | 0.763 |
MITD1 | SPART | ENSBTAP00000005179 | ENSBTAP00000010577 | Microtubule interacting and trafficking domain containing 1. | Spartin; May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis. | 0.701 |