Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
RBP5Retinol-binding protein 5; Intracellular transport of retinol. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)    
Predicted Functional Partners:
BBOX1
Gamma-butyrobetaine hydroxylase 1.
   
  
 0.635
SKAP1
Src kinase associated phosphoprotein 1.
      
 0.631
UPK2
Uroplakin-2; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM; Belongs to the uroplakin-2 family.
      
 0.601
UPK1A
Uroplakin-1a; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions; Belongs to the tetraspanin (TM4SF) family.
      
 0.601
PCSK6
Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family.
   
  
 0.596
TMEM52B
Transmembrane protein 52B.
      
 0.546
ARMH1
Armadillo-like helical domain containing protein 1.
   
  
 0.504
UPK3B
Uroplakin-3b; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity). Belongs to the uroplakin-3 family.
      
 0.457
ENPEP
Glutamyl aminopeptidase; Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II; Belongs to the peptidase M1 family.
      
 0.446
PCSK5
Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family.
   
  
 0.431
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.