node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATF6 | MBTPS1 | ENSBTAP00000053726 | ENSBTAP00000013425 | Activating transcription factor 6. | Membrane bound transcription factor peptidase, site 1. | 0.867 |
ATF6 | MBTPS2 | ENSBTAP00000053726 | ENSBTAP00000062860 | Activating transcription factor 6. | Membrane-bound transcription factor site-2 protease; Involved in regulated intramembrane proteolysis (RIP) that is the cleavage of membrane-spanning regulatory proteins by proteases within the plane of the membrane. It cleaves sterol-regulatory element- binding proteins (SREBPs) within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal fragments shuttle to the nucleus and activate gene transcription. Involved in RIP-mediated regulation of bone formation; Belongs to the peptidase M50A family. | 0.880 |
ATF6 | SREBF2 | ENSBTAP00000053726 | ENSBTAP00000018956 | Activating transcription factor 6. | Sterol regulatory element binding transcription factor 2. | 0.509 |
CREB3L3 | MBTPS1 | ENSBTAP00000013478 | ENSBTAP00000013425 | Processed cyclic AMP-responsive element-binding protein 3-like protein 3; Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds the cAMP response element (CRE). Activates transcription through box-B element and CRE. Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression (By similarity). Belongs to the bZIP family. ATF subfamily. | Membrane bound transcription factor peptidase, site 1. | 0.819 |
CREB3L3 | MBTPS2 | ENSBTAP00000013478 | ENSBTAP00000062860 | Processed cyclic AMP-responsive element-binding protein 3-like protein 3; Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds the cAMP response element (CRE). Activates transcription through box-B element and CRE. Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression (By similarity). Belongs to the bZIP family. ATF subfamily. | Membrane-bound transcription factor site-2 protease; Involved in regulated intramembrane proteolysis (RIP) that is the cleavage of membrane-spanning regulatory proteins by proteases within the plane of the membrane. It cleaves sterol-regulatory element- binding proteins (SREBPs) within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal fragments shuttle to the nucleus and activate gene transcription. Involved in RIP-mediated regulation of bone formation; Belongs to the peptidase M50A family. | 0.818 |
DHDDS | MBTPS2 | ENSBTAP00000010328 | ENSBTAP00000062860 | Alkyl transferase; Belongs to the UPP synthase family. | Membrane-bound transcription factor site-2 protease; Involved in regulated intramembrane proteolysis (RIP) that is the cleavage of membrane-spanning regulatory proteins by proteases within the plane of the membrane. It cleaves sterol-regulatory element- binding proteins (SREBPs) within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal fragments shuttle to the nucleus and activate gene transcription. Involved in RIP-mediated regulation of bone formation; Belongs to the peptidase M50A family. | 0.781 |
DHDDS | NUS1 | ENSBTAP00000010328 | ENSBTAP00000067391 | Alkyl transferase; Belongs to the UPP synthase family. | Uncharacterized protein. | 0.993 |
DHDDS | SAMM50 | ENSBTAP00000010328 | ENSBTAP00000073084 | Alkyl transferase; Belongs to the UPP synthase family. | Sorting and assembly machinery component 50 homolog; Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes. Required for the assembly of TOMM40 into the TOM complex; Belongs to the SAM50/omp85 family. | 0.431 |
MBTPS1 | ATF6 | ENSBTAP00000013425 | ENSBTAP00000053726 | Membrane bound transcription factor peptidase, site 1. | Activating transcription factor 6. | 0.867 |
MBTPS1 | CREB3L3 | ENSBTAP00000013425 | ENSBTAP00000013478 | Membrane bound transcription factor peptidase, site 1. | Processed cyclic AMP-responsive element-binding protein 3-like protein 3; Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds the cAMP response element (CRE). Activates transcription through box-B element and CRE. Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression (By similarity). Belongs to the bZIP family. ATF subfamily. | 0.819 |
MBTPS1 | MBTPS2 | ENSBTAP00000013425 | ENSBTAP00000062860 | Membrane bound transcription factor peptidase, site 1. | Membrane-bound transcription factor site-2 protease; Involved in regulated intramembrane proteolysis (RIP) that is the cleavage of membrane-spanning regulatory proteins by proteases within the plane of the membrane. It cleaves sterol-regulatory element- binding proteins (SREBPs) within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal fragments shuttle to the nucleus and activate gene transcription. Involved in RIP-mediated regulation of bone formation; Belongs to the peptidase M50A family. | 0.868 |
MBTPS1 | SREBF1 | ENSBTAP00000013425 | ENSBTAP00000062207 | Membrane bound transcription factor peptidase, site 1. | Sterol regulatory element binding transcription factor 1. | 0.563 |
MBTPS1 | SREBF2 | ENSBTAP00000013425 | ENSBTAP00000018956 | Membrane bound transcription factor peptidase, site 1. | Sterol regulatory element binding transcription factor 2. | 0.726 |
MBTPS2 | ATF6 | ENSBTAP00000062860 | ENSBTAP00000053726 | Membrane-bound transcription factor site-2 protease; Involved in regulated intramembrane proteolysis (RIP) that is the cleavage of membrane-spanning regulatory proteins by proteases within the plane of the membrane. It cleaves sterol-regulatory element- binding proteins (SREBPs) within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal fragments shuttle to the nucleus and activate gene transcription. Involved in RIP-mediated regulation of bone formation; Belongs to the peptidase M50A family. | Activating transcription factor 6. | 0.880 |
MBTPS2 | CREB3L3 | ENSBTAP00000062860 | ENSBTAP00000013478 | Membrane-bound transcription factor site-2 protease; Involved in regulated intramembrane proteolysis (RIP) that is the cleavage of membrane-spanning regulatory proteins by proteases within the plane of the membrane. It cleaves sterol-regulatory element- binding proteins (SREBPs) within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal fragments shuttle to the nucleus and activate gene transcription. Involved in RIP-mediated regulation of bone formation; Belongs to the peptidase M50A family. | Processed cyclic AMP-responsive element-binding protein 3-like protein 3; Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds the cAMP response element (CRE). Activates transcription through box-B element and CRE. Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression (By similarity). Belongs to the bZIP family. ATF subfamily. | 0.818 |
MBTPS2 | DHDDS | ENSBTAP00000062860 | ENSBTAP00000010328 | Membrane-bound transcription factor site-2 protease; Involved in regulated intramembrane proteolysis (RIP) that is the cleavage of membrane-spanning regulatory proteins by proteases within the plane of the membrane. It cleaves sterol-regulatory element- binding proteins (SREBPs) within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal fragments shuttle to the nucleus and activate gene transcription. Involved in RIP-mediated regulation of bone formation; Belongs to the peptidase M50A family. | Alkyl transferase; Belongs to the UPP synthase family. | 0.781 |
MBTPS2 | MBTPS1 | ENSBTAP00000062860 | ENSBTAP00000013425 | Membrane-bound transcription factor site-2 protease; Involved in regulated intramembrane proteolysis (RIP) that is the cleavage of membrane-spanning regulatory proteins by proteases within the plane of the membrane. It cleaves sterol-regulatory element- binding proteins (SREBPs) within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal fragments shuttle to the nucleus and activate gene transcription. Involved in RIP-mediated regulation of bone formation; Belongs to the peptidase M50A family. | Membrane bound transcription factor peptidase, site 1. | 0.868 |
MBTPS2 | NUS1 | ENSBTAP00000062860 | ENSBTAP00000067391 | Membrane-bound transcription factor site-2 protease; Involved in regulated intramembrane proteolysis (RIP) that is the cleavage of membrane-spanning regulatory proteins by proteases within the plane of the membrane. It cleaves sterol-regulatory element- binding proteins (SREBPs) within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal fragments shuttle to the nucleus and activate gene transcription. Involved in RIP-mediated regulation of bone formation; Belongs to the peptidase M50A family. | Uncharacterized protein. | 0.781 |
MBTPS2 | SAMM50 | ENSBTAP00000062860 | ENSBTAP00000073084 | Membrane-bound transcription factor site-2 protease; Involved in regulated intramembrane proteolysis (RIP) that is the cleavage of membrane-spanning regulatory proteins by proteases within the plane of the membrane. It cleaves sterol-regulatory element- binding proteins (SREBPs) within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal fragments shuttle to the nucleus and activate gene transcription. Involved in RIP-mediated regulation of bone formation; Belongs to the peptidase M50A family. | Sorting and assembly machinery component 50 homolog; Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes. Required for the assembly of TOMM40 into the TOM complex; Belongs to the SAM50/omp85 family. | 0.887 |
MBTPS2 | SREBF1 | ENSBTAP00000062860 | ENSBTAP00000062207 | Membrane-bound transcription factor site-2 protease; Involved in regulated intramembrane proteolysis (RIP) that is the cleavage of membrane-spanning regulatory proteins by proteases within the plane of the membrane. It cleaves sterol-regulatory element- binding proteins (SREBPs) within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal fragments shuttle to the nucleus and activate gene transcription. Involved in RIP-mediated regulation of bone formation; Belongs to the peptidase M50A family. | Sterol regulatory element binding transcription factor 1. | 0.817 |