node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IL22 | S100A7 | ENSBTAP00000020476 | ENSBTAP00000010838 | Interleukin 22. | Protein S100-A7. | 0.642 |
LOC112445860 | LOC786350 | ENSBTAP00000057764 | ENSBTAP00000044105 | Protein S100; Belongs to the S-100 family. | Protein S100; Belongs to the S-100 family. | 0.900 |
LOC112445860 | S100A12 | ENSBTAP00000057764 | ENSBTAP00000034009 | Protein S100; Belongs to the S-100 family. | Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF- kappa-B signaling pathways leadi [...] | 0.441 |
LOC112445860 | S100A7 | ENSBTAP00000057764 | ENSBTAP00000010838 | Protein S100; Belongs to the S-100 family. | Protein S100-A7. | 0.901 |
LOC786350 | LOC112445860 | ENSBTAP00000044105 | ENSBTAP00000057764 | Protein S100; Belongs to the S-100 family. | Protein S100; Belongs to the S-100 family. | 0.900 |
LOC786350 | S100A12 | ENSBTAP00000044105 | ENSBTAP00000034009 | Protein S100; Belongs to the S-100 family. | Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF- kappa-B signaling pathways leadi [...] | 0.441 |
LOC786350 | S100A7 | ENSBTAP00000044105 | ENSBTAP00000010838 | Protein S100; Belongs to the S-100 family. | Protein S100-A7. | 0.901 |
S100A11 | S100A12 | ENSBTAP00000072891 | ENSBTAP00000034009 | Protein S100; Belongs to the S-100 family. | Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF- kappa-B signaling pathways leadi [...] | 0.721 |
S100A11 | S100A16 | ENSBTAP00000072891 | ENSBTAP00000018877 | Protein S100; Belongs to the S-100 family. | Protein S100-A16; Calcium-binding protein. Binds one calcium ion per monomer (By similarity). Can promote differentiation of adipocytes (in vitro) (By similarity). Overexpression in preadipocytes increases their proliferation, enhances adipogenesis and reduces insulin-stimulated glucose uptake (By similarity); Belongs to the S-100 family. | 0.741 |
S100A11 | S100A4 | ENSBTAP00000072891 | ENSBTAP00000025561 | Protein S100; Belongs to the S-100 family. | Protein S100-A4. | 0.719 |
S100A11 | S100A5 | ENSBTAP00000072891 | ENSBTAP00000072975 | Protein S100; Belongs to the S-100 family. | Protein S100; Belongs to the S-100 family. | 0.590 |
S100A11 | S100A7 | ENSBTAP00000072891 | ENSBTAP00000010838 | Protein S100; Belongs to the S-100 family. | Protein S100-A7. | 0.666 |
S100A12 | LOC112445860 | ENSBTAP00000034009 | ENSBTAP00000057764 | Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF- kappa-B signaling pathways leadi [...] | Protein S100; Belongs to the S-100 family. | 0.441 |
S100A12 | LOC786350 | ENSBTAP00000034009 | ENSBTAP00000044105 | Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF- kappa-B signaling pathways leadi [...] | Protein S100; Belongs to the S-100 family. | 0.441 |
S100A12 | S100A11 | ENSBTAP00000034009 | ENSBTAP00000072891 | Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF- kappa-B signaling pathways leadi [...] | Protein S100; Belongs to the S-100 family. | 0.721 |
S100A12 | S100A13 | ENSBTAP00000034009 | ENSBTAP00000058627 | Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF- kappa-B signaling pathways leadi [...] | Protein S100-A13; Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity). | 0.663 |
S100A12 | S100A16 | ENSBTAP00000034009 | ENSBTAP00000018877 | Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF- kappa-B signaling pathways leadi [...] | Protein S100-A16; Calcium-binding protein. Binds one calcium ion per monomer (By similarity). Can promote differentiation of adipocytes (in vitro) (By similarity). Overexpression in preadipocytes increases their proliferation, enhances adipogenesis and reduces insulin-stimulated glucose uptake (By similarity); Belongs to the S-100 family. | 0.483 |
S100A12 | S100A5 | ENSBTAP00000034009 | ENSBTAP00000072975 | Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF- kappa-B signaling pathways leadi [...] | Protein S100; Belongs to the S-100 family. | 0.436 |
S100A12 | S100A7 | ENSBTAP00000034009 | ENSBTAP00000010838 | Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF- kappa-B signaling pathways leadi [...] | Protein S100-A7. | 0.768 |
S100A13 | S100A12 | ENSBTAP00000058627 | ENSBTAP00000034009 | Protein S100-A13; Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity). | Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF- kappa-B signaling pathways leadi [...] | 0.663 |