node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EDNRA | GNAQ | ENSBTAP00000018173 | ENSBTAP00000016160 | Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. | G protein subunit alpha q. | 0.930 |
EDNRA | KCNJ2 | ENSBTAP00000018173 | ENSBTAP00000010914 | Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. | Inward rectifier potassium channel 2; Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be bl [...] | 0.908 |
GNAQ | EDNRA | ENSBTAP00000016160 | ENSBTAP00000018173 | G protein subunit alpha q. | Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. | 0.930 |
GNAQ | KCNJ12 | ENSBTAP00000016160 | ENSBTAP00000056563 | G protein subunit alpha q. | ATP-sensitive inward rectifier potassium channel 12; Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potas [...] | 0.904 |
GNAQ | KCNJ14 | ENSBTAP00000016160 | ENSBTAP00000000089 | G protein subunit alpha q. | Potassium voltage-gated channel subfamily J member 14. | 0.902 |
GNAQ | KCNJ2 | ENSBTAP00000016160 | ENSBTAP00000010914 | G protein subunit alpha q. | Inward rectifier potassium channel 2; Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be bl [...] | 0.904 |
GNAQ | KCNJ4 | ENSBTAP00000016160 | ENSBTAP00000063297 | G protein subunit alpha q. | Potassium voltage-gated channel subfamily J member 4. | 0.903 |
KCNJ12 | GNAQ | ENSBTAP00000056563 | ENSBTAP00000016160 | ATP-sensitive inward rectifier potassium channel 12; Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potas [...] | G protein subunit alpha q. | 0.904 |
KCNJ12 | KCNJ14 | ENSBTAP00000056563 | ENSBTAP00000000089 | ATP-sensitive inward rectifier potassium channel 12; Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potas [...] | Potassium voltage-gated channel subfamily J member 14. | 0.904 |
KCNJ12 | KCNJ2 | ENSBTAP00000056563 | ENSBTAP00000010914 | ATP-sensitive inward rectifier potassium channel 12; Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potas [...] | Inward rectifier potassium channel 2; Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be bl [...] | 0.943 |
KCNJ12 | KCNJ4 | ENSBTAP00000056563 | ENSBTAP00000063297 | ATP-sensitive inward rectifier potassium channel 12; Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potas [...] | Potassium voltage-gated channel subfamily J member 4. | 0.916 |
KCNJ12 | KCNQ1 | ENSBTAP00000056563 | ENSBTAP00000073435 | ATP-sensitive inward rectifier potassium channel 12; Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potas [...] | Uncharacterized protein; Belongs to the potassium channel family. | 0.941 |
KCNJ12 | KCNQ2 | ENSBTAP00000056563 | ENSBTAP00000067696 | ATP-sensitive inward rectifier potassium channel 12; Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potas [...] | Potassium voltage-gated channel subfamily Q member 2; Belongs to the potassium channel family. | 0.942 |
KCNJ12 | KCNQ3 | ENSBTAP00000056563 | ENSBTAP00000027546 | ATP-sensitive inward rectifier potassium channel 12; Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potas [...] | Potassium voltage-gated channel subfamily KQT member 3; Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. | 0.912 |
KCNJ12 | KCNQ4 | ENSBTAP00000056563 | ENSBTAP00000073777 | ATP-sensitive inward rectifier potassium channel 12; Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potas [...] | Potassium voltage-gated channel subfamily Q member 4; Belongs to the potassium channel family. | 0.918 |
KCNJ12 | KCNQ5 | ENSBTAP00000056563 | ENSBTAP00000055988 | ATP-sensitive inward rectifier potassium channel 12; Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potas [...] | Potassium voltage-gated channel subfamily Q member 5; Belongs to the potassium channel family. | 0.922 |
KCNJ14 | GNAQ | ENSBTAP00000000089 | ENSBTAP00000016160 | Potassium voltage-gated channel subfamily J member 14. | G protein subunit alpha q. | 0.902 |
KCNJ14 | KCNJ12 | ENSBTAP00000000089 | ENSBTAP00000056563 | Potassium voltage-gated channel subfamily J member 14. | ATP-sensitive inward rectifier potassium channel 12; Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potas [...] | 0.904 |
KCNJ14 | KCNJ2 | ENSBTAP00000000089 | ENSBTAP00000010914 | Potassium voltage-gated channel subfamily J member 14. | Inward rectifier potassium channel 2; Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be bl [...] | 0.904 |
KCNJ14 | KCNJ4 | ENSBTAP00000000089 | ENSBTAP00000063297 | Potassium voltage-gated channel subfamily J member 14. | Potassium voltage-gated channel subfamily J member 4. | 0.905 |