Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Gene Fusion
Co-occurrence
Co-expression
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[Homology]
Score
PON2Serum paraoxonase/arylesterase 2; Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters; Belongs to the paraoxonase family. (354 aa)    
Predicted Functional Partners:
PON3
Paraoxonase 3.
  
 
0.881
NFYC
Nuclear transcription factor Y subunit gamma; Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors (By similarity).
    
   0.761
LRIG2
Leucine rich repeats and immunoglobulin like domains 2.
    
 
 0.644
PON1
Paraoxonase 1.
  
  
 
0.507
GML
Glycosylphosphatidylinositol anchored molecule like protein.
      
 0.468
LRIG3
Leucine rich repeats and immunoglobulin like domains 3.
    
 
 0.462
RNF130
Ring finger protein 130.
    
   0.454
F1MWI1_BOVIN
Clusterin; Belongs to the clusterin family.
      
 0.454
RAD17
RAD17 checkpoint clamp loader component.
      
 0.444
HDGFL3
HDGF like 3.
      
 0.441
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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