| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AQP1 | AQP11 | ENSBTAP00000000993 | ENSBTAP00000026547 | Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. | Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. | 0.869 |
| AQP1 | AQP12B | ENSBTAP00000000993 | ENSBTAP00000004395 | Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. | Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. | 0.853 |
| AQP1 | AQP2 | ENSBTAP00000000993 | ENSBTAP00000011024 | Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. | Aquaporin-2; Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient; Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.552 |
| AQP1 | AQP3 | ENSBTAP00000000993 | ENSBTAP00000011196 | Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. | Aquaporin-3; Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an [...] | 0.698 |
| AQP1 | AQP4 | ENSBTAP00000000993 | ENSBTAP00000062598 | Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. | Aquaporin-4; Forms a water-specific channel. Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from [...] | 0.589 |
| AQP1 | AQP5 | ENSBTAP00000000993 | ENSBTAP00000065116 | Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. | Aquaporin 5; Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.578 |
| AQP1 | AQP8 | ENSBTAP00000000993 | ENSBTAP00000026884 | Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. | Aquaporin 8; Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.690 |
| AQP1 | LOC538702 | ENSBTAP00000000993 | ENSBTAP00000049717 | Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. | Glycerol kinase; Belongs to the FGGY kinase family. | 0.407 |
| AQP1 | MIP | ENSBTAP00000000993 | ENSBTAP00000013360 | Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. | Lens fiber major intrinsic protein; Water channel. Channel activity is down- regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell- to-cell adhesion and facilitates gap junction coupling. Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.538 |
| AQP1 | NME8 | ENSBTAP00000000993 | ENSBTAP00000044371 | Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. | NME/NM23 family member 8. | 0.467 |
| AQP11 | AQP1 | ENSBTAP00000026547 | ENSBTAP00000000993 | Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. | Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. | 0.869 |
| AQP11 | AQP12B | ENSBTAP00000026547 | ENSBTAP00000004395 | Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. | Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. | 0.544 |
| AQP11 | AQP2 | ENSBTAP00000026547 | ENSBTAP00000011024 | Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. | Aquaporin-2; Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient; Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.884 |
| AQP11 | AQP3 | ENSBTAP00000026547 | ENSBTAP00000011196 | Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. | Aquaporin-3; Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an [...] | 0.914 |
| AQP11 | AQP4 | ENSBTAP00000026547 | ENSBTAP00000062598 | Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. | Aquaporin-4; Forms a water-specific channel. Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from [...] | 0.915 |
| AQP11 | AQP5 | ENSBTAP00000026547 | ENSBTAP00000065116 | Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. | Aquaporin 5; Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.931 |
| AQP11 | AQP8 | ENSBTAP00000026547 | ENSBTAP00000026884 | Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. | Aquaporin 8; Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.966 |
| AQP11 | LOC538702 | ENSBTAP00000026547 | ENSBTAP00000049717 | Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. | Glycerol kinase; Belongs to the FGGY kinase family. | 0.528 |
| AQP11 | MIP | ENSBTAP00000026547 | ENSBTAP00000013360 | Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. | Lens fiber major intrinsic protein; Water channel. Channel activity is down- regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell- to-cell adhesion and facilitates gap junction coupling. Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.608 |
| AQP12B | AQP1 | ENSBTAP00000004395 | ENSBTAP00000000993 | Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. | Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. | 0.853 |
