node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASPSCR1 | PRCC | ENSBTAP00000054549 | ENSBTAP00000000800 | UBX domain-containing protein. | Papillary renal cell carcinoma (Translocation-associated). | 0.840 |
ASPSCR1 | TFE3 | ENSBTAP00000054549 | ENSBTAP00000011237 | UBX domain-containing protein. | Transcription factor E3; Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3') (By similarity). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (By similarity). In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer (By similari [...] | 0.761 |
FLCN | FNIP1 | ENSBTAP00000010532 | ENSBTAP00000072698 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. | Folliculin interacting protein 1. | 0.998 |
FLCN | MCOLN1 | ENSBTAP00000010532 | ENSBTAP00000054510 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. | Mucolipin 1. | 0.474 |
FLCN | MTOR | ENSBTAP00000010532 | ENSBTAP00000020386 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. | 0.554 |
FLCN | RRAGA | ENSBTAP00000010532 | ENSBTAP00000051093 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. | Ras-related GTP-binding protein A; Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. | 0.988 |
FLCN | TFE3 | ENSBTAP00000010532 | ENSBTAP00000011237 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. | Transcription factor E3; Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3') (By similarity). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (By similarity). In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer (By similari [...] | 0.720 |
FLCN | TFEB | ENSBTAP00000010532 | ENSBTAP00000072537 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. | Transcription factor EB. | 0.645 |
FNIP1 | FLCN | ENSBTAP00000072698 | ENSBTAP00000010532 | Folliculin interacting protein 1. | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. | 0.998 |
FNIP1 | RRAGA | ENSBTAP00000072698 | ENSBTAP00000051093 | Folliculin interacting protein 1. | Ras-related GTP-binding protein A; Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. | 0.945 |
FNIP1 | TFE3 | ENSBTAP00000072698 | ENSBTAP00000011237 | Folliculin interacting protein 1. | Transcription factor E3; Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3') (By similarity). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (By similarity). In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer (By similari [...] | 0.646 |
FNIP1 | TFEB | ENSBTAP00000072698 | ENSBTAP00000072537 | Folliculin interacting protein 1. | Transcription factor EB. | 0.419 |
LAMP1 | MCOLN1 | ENSBTAP00000042536 | ENSBTAP00000054510 | Lysosome-associated membrane glycoprotein 1; Belongs to the LAMP family. | Mucolipin 1. | 0.736 |
LAMP1 | MTOR | ENSBTAP00000042536 | ENSBTAP00000020386 | Lysosome-associated membrane glycoprotein 1; Belongs to the LAMP family. | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. | 0.979 |
LAMP1 | RRAGA | ENSBTAP00000042536 | ENSBTAP00000051093 | Lysosome-associated membrane glycoprotein 1; Belongs to the LAMP family. | Ras-related GTP-binding protein A; Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. | 0.500 |
LAMP1 | TFE3 | ENSBTAP00000042536 | ENSBTAP00000011237 | Lysosome-associated membrane glycoprotein 1; Belongs to the LAMP family. | Transcription factor E3; Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3') (By similarity). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (By similarity). In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer (By similari [...] | 0.691 |
LAMP1 | TFEB | ENSBTAP00000042536 | ENSBTAP00000072537 | Lysosome-associated membrane glycoprotein 1; Belongs to the LAMP family. | Transcription factor EB. | 0.913 |
MCOLN1 | FLCN | ENSBTAP00000054510 | ENSBTAP00000010532 | Mucolipin 1. | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. | 0.474 |
MCOLN1 | LAMP1 | ENSBTAP00000054510 | ENSBTAP00000042536 | Mucolipin 1. | Lysosome-associated membrane glycoprotein 1; Belongs to the LAMP family. | 0.736 |
MCOLN1 | MITF | ENSBTAP00000054510 | ENSBTAP00000069811 | Mucolipin 1. | Melanocyte inducing transcription factor. | 0.458 |