node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACLY | CS | ENSBTAP00000059914 | ENSBTAP00000005730 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | 0.996 |
ACLY | ECHS1 | ENSBTAP00000059914 | ENSBTAP00000073344 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Enoyl-CoA hydratase, mitochondrial; Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate (By similarity). Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate (By similarity); Belongs to the enoyl-CoA hydratase/isomerase family. | 0.410 |
ACLY | ENSBTAP00000074413 | ENSBTAP00000059914 | ENSBTAP00000074413 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Uncharacterized protein. | 0.901 |
ACLY | SLC25A1 | ENSBTAP00000059914 | ENSBTAP00000058261 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Tricarboxylate transport protein, mitochondrial; Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. Required for proper neuromuscular junction formation. Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.818 |
CS | ACLY | ENSBTAP00000005730 | ENSBTAP00000059914 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | 0.996 |
CS | CXHXorf56 | ENSBTAP00000005730 | ENSBTAP00000055299 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | UPF0428 protein CXorf56 homolog. | 0.605 |
CS | ECHS1 | ENSBTAP00000005730 | ENSBTAP00000073344 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | Enoyl-CoA hydratase, mitochondrial; Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate (By similarity). Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate (By similarity); Belongs to the enoyl-CoA hydratase/isomerase family. | 0.564 |
CS | GRN | ENSBTAP00000005730 | ENSBTAP00000047776 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | Granulin precursor. | 0.621 |
CS | NDUFS7 | ENSBTAP00000005730 | ENSBTAP00000051744 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. | 0.487 |
CS | POLE2 | ENSBTAP00000005730 | ENSBTAP00000006488 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | DNA polymerase epsilon subunit 2; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). | 0.605 |
CS | SLC25A1 | ENSBTAP00000005730 | ENSBTAP00000058261 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | Tricarboxylate transport protein, mitochondrial; Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. Required for proper neuromuscular junction formation. Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.904 |
CXHXorf56 | CS | ENSBTAP00000055299 | ENSBTAP00000005730 | UPF0428 protein CXorf56 homolog. | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | 0.605 |
CXHXorf56 | ENSBTAP00000074413 | ENSBTAP00000055299 | ENSBTAP00000074413 | UPF0428 protein CXorf56 homolog. | Uncharacterized protein. | 0.605 |
CXHXorf56 | GRN | ENSBTAP00000055299 | ENSBTAP00000047776 | UPF0428 protein CXorf56 homolog. | Granulin precursor. | 0.730 |
CXHXorf56 | POLE2 | ENSBTAP00000055299 | ENSBTAP00000006488 | UPF0428 protein CXorf56 homolog. | DNA polymerase epsilon subunit 2; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). | 0.730 |
CXHXorf56 | SLC25A1 | ENSBTAP00000055299 | ENSBTAP00000058261 | UPF0428 protein CXorf56 homolog. | Tricarboxylate transport protein, mitochondrial; Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. Required for proper neuromuscular junction formation. Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.730 |
ECHS1 | ACLY | ENSBTAP00000073344 | ENSBTAP00000059914 | Enoyl-CoA hydratase, mitochondrial; Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate (By similarity). Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate (By similarity); Belongs to the enoyl-CoA hydratase/isomerase family. | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | 0.410 |
ECHS1 | CS | ENSBTAP00000073344 | ENSBTAP00000005730 | Enoyl-CoA hydratase, mitochondrial; Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate (By similarity). Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate (By similarity); Belongs to the enoyl-CoA hydratase/isomerase family. | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | 0.564 |
ECHS1 | ENSBTAP00000074413 | ENSBTAP00000073344 | ENSBTAP00000074413 | Enoyl-CoA hydratase, mitochondrial; Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate (By similarity). Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate (By similarity); Belongs to the enoyl-CoA hydratase/isomerase family. | Uncharacterized protein. | 0.450 |
ECHS1 | MRPL40 | ENSBTAP00000073344 | ENSBTAP00000026501 | Enoyl-CoA hydratase, mitochondrial; Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate (By similarity). Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate (By similarity); Belongs to the enoyl-CoA hydratase/isomerase family. | Mitochondrial ribosomal protein L40. | 0.509 |