node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATF4 | CAMK1D | ENSBTAP00000023213 | ENSBTAP00000011406 | Cyclic AMP-dependent transcription factor ATF-4; Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to endoplasmic reticulum (ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis [...] | Calcium/calmodulin dependent protein kinase ID; Belongs to the protein kinase superfamily. | 0.685 |
ATF4 | CREB1 | ENSBTAP00000023213 | ENSBTAP00000007201 | Cyclic AMP-dependent transcription factor ATF-4; Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to endoplasmic reticulum (ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis [...] | Cyclic AMP-responsive element-binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-117 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells. | 0.963 |
CALM-2 | CALM3 | ENSBTAP00000074130 | ENSBTAP00000019411 | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). | Uncharacterized protein; Belongs to the calmodulin family. | 0.970 |
CALM-2 | CALML4 | ENSBTAP00000074130 | ENSBTAP00000036380 | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). | Calmodulin-like protein 4; Belongs to the calmodulin family. | 0.973 |
CALM-2 | CALML5 | ENSBTAP00000074130 | ENSBTAP00000018403 | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). | Calmodulin like 5. | 0.971 |
CALM-2 | CAMK1D | ENSBTAP00000074130 | ENSBTAP00000011406 | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). | Calcium/calmodulin dependent protein kinase ID; Belongs to the protein kinase superfamily. | 0.846 |
CALM-2 | CREB1 | ENSBTAP00000074130 | ENSBTAP00000007201 | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). | Cyclic AMP-responsive element-binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-117 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells. | 0.762 |
CALM-2 | DCLK1-2 | ENSBTAP00000074130 | ENSBTAP00000050463 | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). | Uncharacterized protein. | 0.592 |
CALM-2 | NOS3 | ENSBTAP00000074130 | ENSBTAP00000063257 | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). | Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets; Belongs to the NOS family. | 0.989 |
CALM3 | CALM-2 | ENSBTAP00000019411 | ENSBTAP00000074130 | Uncharacterized protein; Belongs to the calmodulin family. | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). | 0.970 |
CALM3 | CALML4 | ENSBTAP00000019411 | ENSBTAP00000036380 | Uncharacterized protein; Belongs to the calmodulin family. | Calmodulin-like protein 4; Belongs to the calmodulin family. | 0.947 |
CALM3 | CALML5 | ENSBTAP00000019411 | ENSBTAP00000018403 | Uncharacterized protein; Belongs to the calmodulin family. | Calmodulin like 5. | 0.945 |
CALM3 | CAMK1D | ENSBTAP00000019411 | ENSBTAP00000011406 | Uncharacterized protein; Belongs to the calmodulin family. | Calcium/calmodulin dependent protein kinase ID; Belongs to the protein kinase superfamily. | 0.844 |
CALM3 | CREB1 | ENSBTAP00000019411 | ENSBTAP00000007201 | Uncharacterized protein; Belongs to the calmodulin family. | Cyclic AMP-responsive element-binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-117 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells. | 0.813 |
CALM3 | DCLK1-2 | ENSBTAP00000019411 | ENSBTAP00000050463 | Uncharacterized protein; Belongs to the calmodulin family. | Uncharacterized protein. | 0.594 |
CALM3 | NOS3 | ENSBTAP00000019411 | ENSBTAP00000063257 | Uncharacterized protein; Belongs to the calmodulin family. | Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets; Belongs to the NOS family. | 0.985 |
CALML4 | CALM-2 | ENSBTAP00000036380 | ENSBTAP00000074130 | Calmodulin-like protein 4; Belongs to the calmodulin family. | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). | 0.973 |
CALML4 | CALM3 | ENSBTAP00000036380 | ENSBTAP00000019411 | Calmodulin-like protein 4; Belongs to the calmodulin family. | Uncharacterized protein; Belongs to the calmodulin family. | 0.947 |
CALML4 | CALML5 | ENSBTAP00000036380 | ENSBTAP00000018403 | Calmodulin-like protein 4; Belongs to the calmodulin family. | Calmodulin like 5. | 0.957 |
CALML4 | CAMK1D | ENSBTAP00000036380 | ENSBTAP00000011406 | Calmodulin-like protein 4; Belongs to the calmodulin family. | Calcium/calmodulin dependent protein kinase ID; Belongs to the protein kinase superfamily. | 0.835 |