STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HSD17B1417-beta-hydroxysteroid dehydrogenase 14; Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro) (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (270 aa)    
Predicted Functional Partners:
DHDH
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase.
  
 
 0.771
ECHDC1
Ethylmalonyl-CoA decarboxylase; Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level; Belongs to the enoyl-CoA hydratase/isomerase family.
  
 0.687
MIOX
Inositol oxygenase; Belongs to the myo-inositol oxygenase family.
   
  
 0.684
CES3
Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.
   
 
 0.625
UROC1
Urocanate hydratase 1.
   
 
 0.612
CHKB
Uncharacterized protein.
      
 0.601
HSD17B3
Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
 
0.592
MOGAT2-3
Uncharacterized protein.
   
  
 0.590
MOGAT2
MOGAT2.
   
  
 0.590
MOGAT2-2
Uncharacterized protein.
   
  
 0.590
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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