node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKT3 | EGFR | ENSBTAP00000023654 | ENSBTAP00000070620 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Receptor protein-tyrosine kinase. | 0.400 |
AKT3 | NRAS | ENSBTAP00000023654 | ENSBTAP00000012897 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | NRAS proto-oncogene, GTPase. | 0.581 |
AKT3 | PIK3CA | ENSBTAP00000023654 | ENSBTAP00000068953 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to v [...] | 0.988 |
AKT3 | PIK3R1 | ENSBTAP00000023654 | ENSBTAP00000014594 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] | 0.984 |
AKT3 | PIK3R2 | ENSBTAP00000023654 | ENSBTAP00000003033 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Phosphatidylinositol 3-kinase regulatory subunit beta; Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein- tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating t [...] | 0.964 |
AKT3 | PIK3R3 | ENSBTAP00000023654 | ENSBTAP00000003878 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Phosphatidylinositol 3-kinase regulatory subunit gamma; Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. | 0.952 |
AKT3 | PTEN | ENSBTAP00000023654 | ENSBTAP00000012499 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Phosphatase and tensin homolog. | 0.887 |
EGFR | AKT3 | ENSBTAP00000070620 | ENSBTAP00000023654 | Receptor protein-tyrosine kinase. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.400 |
EGFR | ERBB2 | ENSBTAP00000070620 | ENSBTAP00000029056 | Receptor protein-tyrosine kinase. | Receptor protein-tyrosine kinase. | 0.998 |
EGFR | NRAS | ENSBTAP00000070620 | ENSBTAP00000012897 | Receptor protein-tyrosine kinase. | NRAS proto-oncogene, GTPase. | 0.988 |
EGFR | PIK3CA | ENSBTAP00000070620 | ENSBTAP00000068953 | Receptor protein-tyrosine kinase. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to v [...] | 0.994 |
EGFR | PIK3R1 | ENSBTAP00000070620 | ENSBTAP00000014594 | Receptor protein-tyrosine kinase. | Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] | 0.990 |
EGFR | PIK3R2 | ENSBTAP00000070620 | ENSBTAP00000003033 | Receptor protein-tyrosine kinase. | Phosphatidylinositol 3-kinase regulatory subunit beta; Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein- tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating t [...] | 0.973 |
EGFR | PIK3R3 | ENSBTAP00000070620 | ENSBTAP00000003878 | Receptor protein-tyrosine kinase. | Phosphatidylinositol 3-kinase regulatory subunit gamma; Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. | 0.969 |
EGFR | PTEN | ENSBTAP00000070620 | ENSBTAP00000012499 | Receptor protein-tyrosine kinase. | Phosphatase and tensin homolog. | 0.940 |
EGFR | RRAS | ENSBTAP00000070620 | ENSBTAP00000027944 | Receptor protein-tyrosine kinase. | Related RAS viral (R-ras) oncogene homolog. | 0.400 |
ERBB2 | EGFR | ENSBTAP00000029056 | ENSBTAP00000070620 | Receptor protein-tyrosine kinase. | Receptor protein-tyrosine kinase. | 0.998 |
ERBB2 | NRAS | ENSBTAP00000029056 | ENSBTAP00000012897 | Receptor protein-tyrosine kinase. | NRAS proto-oncogene, GTPase. | 0.880 |
ERBB2 | PIK3CA | ENSBTAP00000029056 | ENSBTAP00000068953 | Receptor protein-tyrosine kinase. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to v [...] | 0.988 |
ERBB2 | PIK3R1 | ENSBTAP00000029056 | ENSBTAP00000014594 | Receptor protein-tyrosine kinase. | Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] | 0.980 |