STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCINAdseverin; Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (By similarity). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization [...] (715 aa)    
Predicted Functional Partners:
HCLS1
Hematopoietic cell-specific Lyn substrate 1.
    
 
 0.937
CTTN
Cortactin.
    
 
 0.934
GSN
Gelsolin; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis (By similarity).
  
  
0.903
PIP5K1C
Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma.
     
 0.902
PIKFYVE
Phosphoinositide kinase, FYVE-type zinc finger containing.
     
 0.901
PIP5K1A
Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha.
     
 0.901
PIP5K1B
Phosphatidylinositol-4-phosphate 5-kinase type 1 beta.
     
 0.901
PIP4K2C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma; May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum.
     
 0.900
PIP4K2B
Phosphatidylinositol-5-phosphate 4-kinase type 2 beta.
     
 0.900
PIP4K2A
Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha.
     
 0.900
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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