node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FRRS1L | SNCB | ENSBTAP00000047556 | ENSBTAP00000012928 | Ferric chelate reductase 1 like. | Beta-synuclein; May be involved in neuronal plasticity; Belongs to the synuclein family. | 0.458 |
LRPAP1 | SNCB | ENSBTAP00000068362 | ENSBTAP00000012928 | LDL receptor related protein associated protein 1. | Beta-synuclein; May be involved in neuronal plasticity; Belongs to the synuclein family. | 0.507 |
LYPD6B | SNCB | ENSBTAP00000066076 | ENSBTAP00000012928 | LY6/PLAUR domain containing 6B. | Beta-synuclein; May be involved in neuronal plasticity; Belongs to the synuclein family. | 0.575 |
MAPT | SNCA | ENSBTAP00000023284 | ENSBTAP00000021300 | Microtubule-associated protein. | Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] | 0.927 |
MAPT | SNCB | ENSBTAP00000023284 | ENSBTAP00000012928 | Microtubule-associated protein. | Beta-synuclein; May be involved in neuronal plasticity; Belongs to the synuclein family. | 0.474 |
MAPT | SNCG | ENSBTAP00000023284 | ENSBTAP00000071939 | Microtubule-associated protein. | Gamma-synuclein; Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. | 0.468 |
MAPT | SYN1 | ENSBTAP00000023284 | ENSBTAP00000027503 | Microtubule-associated protein. | Synapsin-1; Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). | 0.671 |
NRSN2 | SNCB | ENSBTAP00000058017 | ENSBTAP00000012928 | NRSN2 protein. | Beta-synuclein; May be involved in neuronal plasticity; Belongs to the synuclein family. | 0.502 |
PLTP | SNCB | ENSBTAP00000000732 | ENSBTAP00000012928 | Phospholipid transfer protein isoform a. | Beta-synuclein; May be involved in neuronal plasticity; Belongs to the synuclein family. | 0.456 |
SNCA | MAPT | ENSBTAP00000021300 | ENSBTAP00000023284 | Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] | Microtubule-associated protein. | 0.927 |
SNCA | SNCB | ENSBTAP00000021300 | ENSBTAP00000012928 | Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] | Beta-synuclein; May be involved in neuronal plasticity; Belongs to the synuclein family. | 0.584 |
SNCA | SNCG | ENSBTAP00000021300 | ENSBTAP00000071939 | Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] | Gamma-synuclein; Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. | 0.689 |
SNCA | SYN1 | ENSBTAP00000021300 | ENSBTAP00000027503 | Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] | Synapsin-1; Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (By similarity). | 0.660 |
SNCB | FRRS1L | ENSBTAP00000012928 | ENSBTAP00000047556 | Beta-synuclein; May be involved in neuronal plasticity; Belongs to the synuclein family. | Ferric chelate reductase 1 like. | 0.458 |
SNCB | LRPAP1 | ENSBTAP00000012928 | ENSBTAP00000068362 | Beta-synuclein; May be involved in neuronal plasticity; Belongs to the synuclein family. | LDL receptor related protein associated protein 1. | 0.507 |
SNCB | LYPD6B | ENSBTAP00000012928 | ENSBTAP00000066076 | Beta-synuclein; May be involved in neuronal plasticity; Belongs to the synuclein family. | LY6/PLAUR domain containing 6B. | 0.575 |
SNCB | MAPT | ENSBTAP00000012928 | ENSBTAP00000023284 | Beta-synuclein; May be involved in neuronal plasticity; Belongs to the synuclein family. | Microtubule-associated protein. | 0.474 |
SNCB | NRSN2 | ENSBTAP00000012928 | ENSBTAP00000058017 | Beta-synuclein; May be involved in neuronal plasticity; Belongs to the synuclein family. | NRSN2 protein. | 0.502 |
SNCB | PLTP | ENSBTAP00000012928 | ENSBTAP00000000732 | Beta-synuclein; May be involved in neuronal plasticity; Belongs to the synuclein family. | Phospholipid transfer protein isoform a. | 0.456 |
SNCB | SNCA | ENSBTAP00000012928 | ENSBTAP00000021300 | Beta-synuclein; May be involved in neuronal plasticity; Belongs to the synuclein family. | Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] | 0.584 |