node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARNTL | ARNTL2 | ENSBTAP00000057969 | ENSBTAP00000040847 | Aryl hydrocarbon receptor nuclear translocator like. | Aryl hydrocarbon receptor nuclear translocator like 2. | 0.807 |
ARNTL | BHLHE40 | ENSBTAP00000057969 | ENSBTAP00000013008 | Aryl hydrocarbon receptor nuclear translocator like. | Class E basic helix-loop-helix protein 40; Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK- ARNTL/BMAL1|ARNTL2/ [...] | 0.553 |
ARNTL | BHLHE41 | ENSBTAP00000057969 | ENSBTAP00000040772 | Aryl hydrocarbon receptor nuclear translocator like. | Basic helix-loop-helix family, member e41. | 0.765 |
ARNTL | CLOCK | ENSBTAP00000057969 | ENSBTAP00000070979 | Aryl hydrocarbon receptor nuclear translocator like. | Clock circadian regulator. | 0.992 |
ARNTL | CRY1 | ENSBTAP00000057969 | ENSBTAP00000051134 | Aryl hydrocarbon receptor nuclear translocator like. | Cryptochrome circadian regulator 1. | 0.999 |
ARNTL | NR1D1 | ENSBTAP00000057969 | ENSBTAP00000065454 | Aryl hydrocarbon receptor nuclear translocator like. | Nuclear receptor subfamily 1 group D member 1; Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARTNL/BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for [...] | 0.797 |
ARNTL | NR1D2 | ENSBTAP00000057969 | ENSBTAP00000023994 | Aryl hydrocarbon receptor nuclear translocator like. | Nuclear receptor subfamily 1 group D member 2. | 0.814 |
ARNTL | PER2 | ENSBTAP00000057969 | ENSBTAP00000002448 | Aryl hydrocarbon receptor nuclear translocator like. | PAS domain-containing protein. | 0.981 |
ARNTL | PER3 | ENSBTAP00000057969 | ENSBTAP00000058264 | Aryl hydrocarbon receptor nuclear translocator like. | PAS domain-containing protein. | 0.756 |
ARNTL2 | ARNTL | ENSBTAP00000040847 | ENSBTAP00000057969 | Aryl hydrocarbon receptor nuclear translocator like 2. | Aryl hydrocarbon receptor nuclear translocator like. | 0.807 |
ARNTL2 | BHLHE40 | ENSBTAP00000040847 | ENSBTAP00000013008 | Aryl hydrocarbon receptor nuclear translocator like 2. | Class E basic helix-loop-helix protein 40; Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK- ARNTL/BMAL1|ARNTL2/ [...] | 0.524 |
ARNTL2 | BHLHE41 | ENSBTAP00000040847 | ENSBTAP00000040772 | Aryl hydrocarbon receptor nuclear translocator like 2. | Basic helix-loop-helix family, member e41. | 0.645 |
ARNTL2 | CLOCK | ENSBTAP00000040847 | ENSBTAP00000070979 | Aryl hydrocarbon receptor nuclear translocator like 2. | Clock circadian regulator. | 0.848 |
ARNTL2 | CRY1 | ENSBTAP00000040847 | ENSBTAP00000051134 | Aryl hydrocarbon receptor nuclear translocator like 2. | Cryptochrome circadian regulator 1. | 0.841 |
ARNTL2 | NR1D1 | ENSBTAP00000040847 | ENSBTAP00000065454 | Aryl hydrocarbon receptor nuclear translocator like 2. | Nuclear receptor subfamily 1 group D member 1; Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARTNL/BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for [...] | 0.651 |
ARNTL2 | NR1D2 | ENSBTAP00000040847 | ENSBTAP00000023994 | Aryl hydrocarbon receptor nuclear translocator like 2. | Nuclear receptor subfamily 1 group D member 2. | 0.727 |
ARNTL2 | PER2 | ENSBTAP00000040847 | ENSBTAP00000002448 | Aryl hydrocarbon receptor nuclear translocator like 2. | PAS domain-containing protein. | 0.634 |
ARNTL2 | PER3 | ENSBTAP00000040847 | ENSBTAP00000058264 | Aryl hydrocarbon receptor nuclear translocator like 2. | PAS domain-containing protein. | 0.648 |
BHLHE40 | ARNTL | ENSBTAP00000013008 | ENSBTAP00000057969 | Class E basic helix-loop-helix protein 40; Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK- ARNTL/BMAL1|ARNTL2/ [...] | Aryl hydrocarbon receptor nuclear translocator like. | 0.553 |
BHLHE40 | ARNTL2 | ENSBTAP00000013008 | ENSBTAP00000040847 | Class E basic helix-loop-helix protein 40; Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK- ARNTL/BMAL1|ARNTL2/ [...] | Aryl hydrocarbon receptor nuclear translocator like 2. | 0.524 |