Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKT1S1 | DEPTOR | ENSBTAP00000007575 | ENSBTAP00000061795 | AKT1 substrate 1. | DEP domain containing MTOR interacting protein. | 0.953 |
| AKT1S1 | EIF4EBP1 | ENSBTAP00000007575 | ENSBTAP00000039615 | AKT1 substrate 1. | Eukaryotic translation initiation factor 4E-binding protein 1; Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. | 0.947 |
| AKT1S1 | MAPKAP1 | ENSBTAP00000007575 | ENSBTAP00000063173 | AKT1 substrate 1. | Target of rapamycin complex 2 subunit MAPKAP1; Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the [...] | 0.979 |
| AKT1S1 | MLST8 | ENSBTAP00000007575 | ENSBTAP00000013104 | AKT1 substrate 1. | Target of rapamycin complex subunit LST8; Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-r [...] | 0.988 |
| AKT1S1 | MTOR | ENSBTAP00000007575 | ENSBTAP00000020386 | AKT1 substrate 1. | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. | 0.995 |
| AKT1S1 | PRR5 | ENSBTAP00000007575 | ENSBTAP00000066299 | AKT1 substrate 1. | Proline rich 5. | 0.603 |
| AKT1S1 | RHEB | ENSBTAP00000007575 | ENSBTAP00000050644 | AKT1 substrate 1. | GTP-binding protein Rheb; Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity (By similarity). | 0.950 |
| AKT1S1 | RICTOR | ENSBTAP00000007575 | ENSBTAP00000058162 | AKT1 substrate 1. | RPTOR independent companion of MTOR complex 2. | 0.782 |
| AKT1S1 | RPTOR | ENSBTAP00000007575 | ENSBTAP00000003739 | AKT1 substrate 1. | Regulatory associated protein of MTOR complex 1. | 0.998 |
| AKT1S1 | TTI1 | ENSBTAP00000007575 | ENSBTAP00000057134 | AKT1 substrate 1. | TELO2 interacting protein 1. | 0.641 |
| DEPTOR | AKT1S1 | ENSBTAP00000061795 | ENSBTAP00000007575 | DEP domain containing MTOR interacting protein. | AKT1 substrate 1. | 0.953 |
| DEPTOR | EIF4EBP1 | ENSBTAP00000061795 | ENSBTAP00000039615 | DEP domain containing MTOR interacting protein. | Eukaryotic translation initiation factor 4E-binding protein 1; Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. | 0.659 |
| DEPTOR | MAPKAP1 | ENSBTAP00000061795 | ENSBTAP00000063173 | DEP domain containing MTOR interacting protein. | Target of rapamycin complex 2 subunit MAPKAP1; Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the [...] | 0.996 |
| DEPTOR | MLST8 | ENSBTAP00000061795 | ENSBTAP00000013104 | DEP domain containing MTOR interacting protein. | Target of rapamycin complex subunit LST8; Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-r [...] | 0.999 |
| DEPTOR | MTOR | ENSBTAP00000061795 | ENSBTAP00000020386 | DEP domain containing MTOR interacting protein. | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. | 0.992 |
| DEPTOR | PRR5 | ENSBTAP00000061795 | ENSBTAP00000066299 | DEP domain containing MTOR interacting protein. | Proline rich 5. | 0.946 |
| DEPTOR | RHEB | ENSBTAP00000061795 | ENSBTAP00000050644 | DEP domain containing MTOR interacting protein. | GTP-binding protein Rheb; Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity (By similarity). | 0.984 |
| DEPTOR | RICTOR | ENSBTAP00000061795 | ENSBTAP00000058162 | DEP domain containing MTOR interacting protein. | RPTOR independent companion of MTOR complex 2. | 0.998 |
| DEPTOR | RPTOR | ENSBTAP00000061795 | ENSBTAP00000003739 | DEP domain containing MTOR interacting protein. | Regulatory associated protein of MTOR complex 1. | 0.999 |
| DEPTOR | TTI1 | ENSBTAP00000061795 | ENSBTAP00000057134 | DEP domain containing MTOR interacting protein. | TELO2 interacting protein 1. | 0.990 |
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