STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CALR3Calreticulin-3 precursor; During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. CALR3 capacity for calcium-binding may be absent or much lower than that of CALR. Required for sperm fertility (By similarity) (384 aa)    
Predicted Functional Partners:
PDILT
Protein disulfide-isomerase-like protein of the testis precursor; Protein disulfide isomerase-like, testis expressed
   
 
 0.892
HSP90B1
Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity); Belongs to the heat shock protein 90 family
   
 
 0.860
PRSS37
Probable inactive serine protease 37; Plays a role in male fertility. May have a role in sperm migration or binding to zona-intact eggs. Involved in the activation of the proacrosin/acrosin system
   
 
 0.816
TPST2
Protein-tyrosine sulfotransferase 2 precursor; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate
      
 0.764
ADAM2
Disintegrin and metalloproteinase domain-containing protein 2 precursor; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity)
    
 
 0.730
ENSBTAP00000052422
annotation not available
   
 
 0.671
CCDC110
Coiled-coil domain-containing protein 110 isoform x1; Coiled-coil domain containing 110
      
 0.666
SPATA19
Spermatogenesis-associated protein 19, mitochondrial; May have a role in spermiogenesis
      
 0.665
ADAM1B
Disintegrin and metalloproteinase domain-containing protein 1b; Uncharacterized protein; Bos taurus a disintegrin and metallopeptidase domain 1b (ADAM1B), mRNA
    
 
 0.663
SSB
Lupus La protein homolog; Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation
   
 
 0.652
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, domestic cattle, domestic cow
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