node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAM1A | CALR3 | ENSBTAP00000042376 | ENSBTAP00000013175 | Uncharacterized protein. | Calreticulin-3; During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. CALR3 capacity for calcium-binding may be absent or much lower than that of CALR. Required for sperm fertility (By similarity); Belongs to the calreticulin family. | 0.747 |
ADAM1A | PDILT | ENSBTAP00000042376 | ENSBTAP00000021853 | Uncharacterized protein. | Protein disulfide isomerase like, testis expressed. | 0.824 |
ADAM1A | PRSS55 | ENSBTAP00000042376 | ENSBTAP00000046176 | Uncharacterized protein. | Serine protease 55; Belongs to the peptidase S1 family. | 0.687 |
ADAM2 | CALR3 | ENSBTAP00000012384 | ENSBTAP00000013175 | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). | Calreticulin-3; During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. CALR3 capacity for calcium-binding may be absent or much lower than that of CALR. Required for sperm fertility (By similarity); Belongs to the calreticulin family. | 0.632 |
ADAM2 | PDILT | ENSBTAP00000012384 | ENSBTAP00000021853 | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). | Protein disulfide isomerase like, testis expressed. | 0.727 |
ADAM2 | PRSS55 | ENSBTAP00000012384 | ENSBTAP00000046176 | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). | Serine protease 55; Belongs to the peptidase S1 family. | 0.688 |
CALR3 | ADAM1A | ENSBTAP00000013175 | ENSBTAP00000042376 | Calreticulin-3; During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. CALR3 capacity for calcium-binding may be absent or much lower than that of CALR. Required for sperm fertility (By similarity); Belongs to the calreticulin family. | Uncharacterized protein. | 0.747 |
CALR3 | ADAM2 | ENSBTAP00000013175 | ENSBTAP00000012384 | Calreticulin-3; During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. CALR3 capacity for calcium-binding may be absent or much lower than that of CALR. Required for sperm fertility (By similarity); Belongs to the calreticulin family. | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). | 0.632 |
CALR3 | CCDC110 | ENSBTAP00000013175 | ENSBTAP00000022809 | Calreticulin-3; During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. CALR3 capacity for calcium-binding may be absent or much lower than that of CALR. Required for sperm fertility (By similarity); Belongs to the calreticulin family. | Coiled-coil domain containing 110. | 0.656 |
CALR3 | HSP90B1 | ENSBTAP00000013175 | ENSBTAP00000004364 | Calreticulin-3; During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. CALR3 capacity for calcium-binding may be absent or much lower than that of CALR. Required for sperm fertility (By similarity); Belongs to the calreticulin family. | Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. Belongs to the heat shock protein 90 family. | 0.870 |
CALR3 | HSPA5 | ENSBTAP00000013175 | ENSBTAP00000052422 | Calreticulin-3; During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. CALR3 capacity for calcium-binding may be absent or much lower than that of CALR. Required for sperm fertility (By similarity); Belongs to the calreticulin family. | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] | 0.672 |
CALR3 | PDIA3 | ENSBTAP00000013175 | ENSBTAP00000022854 | Calreticulin-3; During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. CALR3 capacity for calcium-binding may be absent or much lower than that of CALR. Required for sperm fertility (By similarity); Belongs to the calreticulin family. | Protein disulfide-isomerase A3. | 0.807 |
CALR3 | PDIA4 | ENSBTAP00000013175 | ENSBTAP00000022782 | Calreticulin-3; During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. CALR3 capacity for calcium-binding may be absent or much lower than that of CALR. Required for sperm fertility (By similarity); Belongs to the calreticulin family. | Protein disulfide-isomerase A4. | 0.668 |
CALR3 | PDILT | ENSBTAP00000013175 | ENSBTAP00000021853 | Calreticulin-3; During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. CALR3 capacity for calcium-binding may be absent or much lower than that of CALR. Required for sperm fertility (By similarity); Belongs to the calreticulin family. | Protein disulfide isomerase like, testis expressed. | 0.801 |
CALR3 | PRSS55 | ENSBTAP00000013175 | ENSBTAP00000046176 | Calreticulin-3; During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. CALR3 capacity for calcium-binding may be absent or much lower than that of CALR. Required for sperm fertility (By similarity); Belongs to the calreticulin family. | Serine protease 55; Belongs to the peptidase S1 family. | 0.684 |
CALR3 | TAPBP | ENSBTAP00000013175 | ENSBTAP00000022386 | Calreticulin-3; During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. CALR3 capacity for calcium-binding may be absent or much lower than that of CALR. Required for sperm fertility (By similarity); Belongs to the calreticulin family. | TAP binding protein (Tapasin). | 0.787 |
CCDC110 | CALR3 | ENSBTAP00000022809 | ENSBTAP00000013175 | Coiled-coil domain containing 110. | Calreticulin-3; During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. CALR3 capacity for calcium-binding may be absent or much lower than that of CALR. Required for sperm fertility (By similarity); Belongs to the calreticulin family. | 0.656 |
HSP90B1 | CALR3 | ENSBTAP00000004364 | ENSBTAP00000013175 | Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. Belongs to the heat shock protein 90 family. | Calreticulin-3; During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. CALR3 capacity for calcium-binding may be absent or much lower than that of CALR. Required for sperm fertility (By similarity); Belongs to the calreticulin family. | 0.870 |
HSP90B1 | HSPA5 | ENSBTAP00000004364 | ENSBTAP00000052422 | Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. Belongs to the heat shock protein 90 family. | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] | 0.999 |
HSP90B1 | PDIA3 | ENSBTAP00000004364 | ENSBTAP00000022854 | Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. Belongs to the heat shock protein 90 family. | Protein disulfide-isomerase A3. | 0.989 |