node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGEF12 | PLXNB3 | ENSBTAP00000073305 | ENSBTAP00000013391 | Rho guanine nucleotide exchange factor 12. | Plexin B3. | 0.943 |
ARHGEF12 | RND1 | ENSBTAP00000073305 | ENSBTAP00000024996 | Rho guanine nucleotide exchange factor 12. | Rho-related GTP-binding protein Rho6; Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments (By similarity). | 0.743 |
ARHGEF12 | RRAS | ENSBTAP00000073305 | ENSBTAP00000027944 | Rho guanine nucleotide exchange factor 12. | Related RAS viral (R-ras) oncogene homolog. | 0.918 |
ARHGEF12 | SEMA4D | ENSBTAP00000073305 | ENSBTAP00000061871 | Rho guanine nucleotide exchange factor 12. | Semaphorin 4D; Belongs to the semaphorin family. | 0.591 |
PLXNB3 | ARHGEF12 | ENSBTAP00000013391 | ENSBTAP00000073305 | Plexin B3. | Rho guanine nucleotide exchange factor 12. | 0.943 |
PLXNB3 | RAC3 | ENSBTAP00000013391 | ENSBTAP00000067666 | Plexin B3. | Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...] | 0.953 |
PLXNB3 | RND1 | ENSBTAP00000013391 | ENSBTAP00000024996 | Plexin B3. | Rho-related GTP-binding protein Rho6; Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments (By similarity). | 0.975 |
PLXNB3 | RRAS | ENSBTAP00000013391 | ENSBTAP00000027944 | Plexin B3. | Related RAS viral (R-ras) oncogene homolog. | 0.949 |
PLXNB3 | SEMA4A | ENSBTAP00000013391 | ENSBTAP00000016223 | Plexin B3. | Semaphorin-4A; Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling (By similarity). Regulates glutamatergic and GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner (By similarity). Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T- helper cells, and thereby contributes to adaptive immunity (By similarity). Promotes phosphorylation of TIMD2 (By [...] | 0.940 |
PLXNB3 | SEMA4C | ENSBTAP00000013391 | ENSBTAP00000059616 | Plexin B3. | Semaphorin 4C; Belongs to the semaphorin family. | 0.980 |
PLXNB3 | SEMA4D | ENSBTAP00000013391 | ENSBTAP00000061871 | Plexin B3. | Semaphorin 4D; Belongs to the semaphorin family. | 0.992 |
PLXNB3 | SEMA4F | ENSBTAP00000013391 | ENSBTAP00000009186 | Plexin B3. | Ssemaphorin 4F; Belongs to the semaphorin family. | 0.946 |
PLXNB3 | SEMA4G | ENSBTAP00000013391 | ENSBTAP00000024759 | Plexin B3. | SEMA4G protein; Belongs to the semaphorin family. | 0.938 |
PLXNB3 | SEMA5A | ENSBTAP00000013391 | ENSBTAP00000062629 | Plexin B3. | Semaphorin 5A. | 0.986 |
RAC3 | PLXNB3 | ENSBTAP00000067666 | ENSBTAP00000013391 | Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...] | Plexin B3. | 0.953 |
RAC3 | RND1 | ENSBTAP00000067666 | ENSBTAP00000024996 | Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...] | Rho-related GTP-binding protein Rho6; Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments (By similarity). | 0.574 |
RND1 | ARHGEF12 | ENSBTAP00000024996 | ENSBTAP00000073305 | Rho-related GTP-binding protein Rho6; Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments (By similarity). | Rho guanine nucleotide exchange factor 12. | 0.743 |
RND1 | PLXNB3 | ENSBTAP00000024996 | ENSBTAP00000013391 | Rho-related GTP-binding protein Rho6; Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments (By similarity). | Plexin B3. | 0.975 |
RND1 | RAC3 | ENSBTAP00000024996 | ENSBTAP00000067666 | Rho-related GTP-binding protein Rho6; Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments (By similarity). | Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...] | 0.574 |
RND1 | RRAS | ENSBTAP00000024996 | ENSBTAP00000027944 | Rho-related GTP-binding protein Rho6; Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments (By similarity). | Related RAS viral (R-ras) oncogene homolog. | 0.825 |