Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARHGEF6 | ARHGEF7 | ENSBTAP00000023731 | ENSBTAP00000027619 | Rac/Cdc42 guanine nucleotide exchange factor 6. | Rho guanine nucleotide exchange factor 7. | 0.942 |
| ARHGEF6 | CDC42 | ENSBTAP00000023731 | ENSBTAP00000059852 | Rac/Cdc42 guanine nucleotide exchange factor 6. | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | 0.779 |
| ARHGEF6 | PAK1 | ENSBTAP00000023731 | ENSBTAP00000013448 | Rac/Cdc42 guanine nucleotide exchange factor 6. | Serine/threonine-protein kinase PAK 1; Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby media [...] | 0.961 |
| ARHGEF6 | RAC1 | ENSBTAP00000023731 | ENSBTAP00000064503 | Rac/Cdc42 guanine nucleotide exchange factor 6. | Ras-related C3 botulinum toxin substrate 1. | 0.614 |
| ARHGEF6 | RAC2 | ENSBTAP00000023731 | ENSBTAP00000014666 | Rac/Cdc42 guanine nucleotide exchange factor 6. | Ras-related C3 botulinum toxin substrate 2; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase (By similarity). | 0.942 |
| ARHGEF6 | RAC3 | ENSBTAP00000023731 | ENSBTAP00000067666 | Rac/Cdc42 guanine nucleotide exchange factor 6. | Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...] | 0.935 |
| ARHGEF6 | RHOA | ENSBTAP00000023731 | ENSBTAP00000005600 | Rac/Cdc42 guanine nucleotide exchange factor 6. | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.632 |
| ARHGEF7 | ARHGEF6 | ENSBTAP00000027619 | ENSBTAP00000023731 | Rho guanine nucleotide exchange factor 7. | Rac/Cdc42 guanine nucleotide exchange factor 6. | 0.942 |
| ARHGEF7 | CDC42 | ENSBTAP00000027619 | ENSBTAP00000059852 | Rho guanine nucleotide exchange factor 7. | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | 0.977 |
| ARHGEF7 | NCK1 | ENSBTAP00000027619 | ENSBTAP00000024518 | Rho guanine nucleotide exchange factor 7. | Cytoplasmic protein. | 0.581 |
| ARHGEF7 | NCK2 | ENSBTAP00000027619 | ENSBTAP00000072385 | Rho guanine nucleotide exchange factor 7. | Cytoplasmic protein. | 0.623 |
| ARHGEF7 | PAK1 | ENSBTAP00000027619 | ENSBTAP00000013448 | Rho guanine nucleotide exchange factor 7. | Serine/threonine-protein kinase PAK 1; Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby media [...] | 0.965 |
| ARHGEF7 | RAC1 | ENSBTAP00000027619 | ENSBTAP00000064503 | Rho guanine nucleotide exchange factor 7. | Ras-related C3 botulinum toxin substrate 1. | 0.705 |
| ARHGEF7 | RAC2 | ENSBTAP00000027619 | ENSBTAP00000014666 | Rho guanine nucleotide exchange factor 7. | Ras-related C3 botulinum toxin substrate 2; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase (By similarity). | 0.935 |
| ARHGEF7 | RAC3 | ENSBTAP00000027619 | ENSBTAP00000067666 | Rho guanine nucleotide exchange factor 7. | Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...] | 0.942 |
| ARHGEF7 | RHOA | ENSBTAP00000027619 | ENSBTAP00000005600 | Rho guanine nucleotide exchange factor 7. | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.634 |
| CDC42 | ARHGEF6 | ENSBTAP00000059852 | ENSBTAP00000023731 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Rac/Cdc42 guanine nucleotide exchange factor 6. | 0.779 |
| CDC42 | ARHGEF7 | ENSBTAP00000059852 | ENSBTAP00000027619 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Rho guanine nucleotide exchange factor 7. | 0.977 |
| CDC42 | NCK1 | ENSBTAP00000059852 | ENSBTAP00000024518 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Cytoplasmic protein. | 0.808 |
| CDC42 | NCK2 | ENSBTAP00000059852 | ENSBTAP00000072385 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Cytoplasmic protein. | 0.730 |
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