node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DUS2 | PUS1 | ENSBTAP00000019500 | ENSBTAP00000017270 | Dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae). | Pseudouridine synthase 1. | 0.698 |
DUS2 | THG1L | ENSBTAP00000019500 | ENSBTAP00000013678 | Dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae). | Probable tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. | 0.612 |
DUS2 | TRMT5 | ENSBTAP00000019500 | ENSBTAP00000063143 | Dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae). | tRNA (guanine(37)-N1)-methyltransferase; Involved in mitochondrial tRNA methylation (By similarity). Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family. | 0.813 |
DUS2 | TRMT61B | ENSBTAP00000019500 | ENSBTAP00000073086 | Dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae). | tRNA methyltransferase 61B. | 0.749 |
DUS2 | TRNT1 | ENSBTAP00000019500 | ENSBTAP00000073307 | Dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae). | tRNA nucleotidyl transferase, CCA-adding, 1; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. | 0.512 |
GTPBP6 | LRCH4 | ENSBTAP00000060010 | ENSBTAP00000037062 | GTP binding protein 6 (putative). | Leucine rich repeats and calponin homology domain containing 4. | 0.621 |
GTPBP6 | PDE12 | ENSBTAP00000060010 | ENSBTAP00000020675 | GTP binding protein 6 (putative). | 2',5'-phosphodiesterase 12; Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured [...] | 0.450 |
GTPBP6 | THG1L | ENSBTAP00000060010 | ENSBTAP00000013678 | GTP binding protein 6 (putative). | Probable tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. | 0.622 |
HARS1 | HARS2 | ENSBTAP00000025094 | ENSBTAP00000035214 | Histidine--tRNA ligase, cytoplasmic; Catalyzes the ATP-dependent ligation of histidine to the 3'- end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance. Belongs to the class-II aminoacyl-tRNA synthetase family. | Histidine--tRNA ligase, mitochondrial; Mitochondrial aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). | 0.914 |
HARS1 | THG1L | ENSBTAP00000025094 | ENSBTAP00000013678 | Histidine--tRNA ligase, cytoplasmic; Catalyzes the ATP-dependent ligation of histidine to the 3'- end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance. Belongs to the class-II aminoacyl-tRNA synthetase family. | Probable tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. | 0.809 |
HARS1 | TRNT1 | ENSBTAP00000025094 | ENSBTAP00000073307 | Histidine--tRNA ligase, cytoplasmic; Catalyzes the ATP-dependent ligation of histidine to the 3'- end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance. Belongs to the class-II aminoacyl-tRNA synthetase family. | tRNA nucleotidyl transferase, CCA-adding, 1; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. | 0.570 |
HARS2 | HARS1 | ENSBTAP00000035214 | ENSBTAP00000025094 | Histidine--tRNA ligase, mitochondrial; Mitochondrial aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). | Histidine--tRNA ligase, cytoplasmic; Catalyzes the ATP-dependent ligation of histidine to the 3'- end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance. Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.914 |
HARS2 | THG1L | ENSBTAP00000035214 | ENSBTAP00000013678 | Histidine--tRNA ligase, mitochondrial; Mitochondrial aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). | Probable tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. | 0.815 |
HARS2 | TRNT1 | ENSBTAP00000035214 | ENSBTAP00000073307 | Histidine--tRNA ligase, mitochondrial; Mitochondrial aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). | tRNA nucleotidyl transferase, CCA-adding, 1; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. | 0.614 |
LRCH4 | GTPBP6 | ENSBTAP00000037062 | ENSBTAP00000060010 | Leucine rich repeats and calponin homology domain containing 4. | GTP binding protein 6 (putative). | 0.621 |
LRCH4 | THG1L | ENSBTAP00000037062 | ENSBTAP00000013678 | Leucine rich repeats and calponin homology domain containing 4. | Probable tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. | 0.660 |
PDE12 | GTPBP6 | ENSBTAP00000020675 | ENSBTAP00000060010 | 2',5'-phosphodiesterase 12; Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured [...] | GTP binding protein 6 (putative). | 0.450 |
PDE12 | THG1L | ENSBTAP00000020675 | ENSBTAP00000013678 | 2',5'-phosphodiesterase 12; Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured [...] | Probable tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. | 0.666 |
PDE12 | TRMT61B | ENSBTAP00000020675 | ENSBTAP00000073086 | 2',5'-phosphodiesterase 12; Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured [...] | tRNA methyltransferase 61B. | 0.430 |
PDE12 | TRNT1 | ENSBTAP00000020675 | ENSBTAP00000073307 | 2',5'-phosphodiesterase 12; Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured [...] | tRNA nucleotidyl transferase, CCA-adding, 1; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. | 0.624 |