Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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ACAP1Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1; GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration (By similarity). (760 aa)    
Predicted Functional Partners:
AGFG2
ArfGAP with FG repeats 2.
      
 0.855
ARF6
ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.
    
 0.832
APPL1
Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.
   
0.755
PTPRCAP
Protein tyrosine phosphatase receptor type C-associated protein.
   
  
 0.721
APPL2
Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2.
   
 0.680
RASAL3
RAS protein activator like-3; Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down- stream ERK signaling pathway.
   
 
 0.668
SKAP1
Src kinase associated phosphoprotein 1.
   
  
 0.639
ARFGAP1
ADP ribosylation factor GTPase activating protein 1.
    
 0.593
VAV1
Proto-oncogene vav; Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.
   
  
 0.590
ARAP1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1.
   
0.590
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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