STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPADH1Spermadhesin-1; Stimulates cell division and progesterone secretion of bovine granulosa cells in vitro in a potent and dose dependent manner. This protein appears to be a potent growth factor with effects on ovarian granulosa cells. (134 aa)    
Predicted Functional Partners:
BSP1
Seminal plasma protein PDC-109; Could enhance the fertilizing capacity of bull spermatozoa upon interaction with heparin-like glycosaminoglycans present in the female genital tract. Exhibits both simulatory and inhibitory actions on the release of pituitary gonadotropins.
   
 
 0.867
BSP3
Seminal plasma protein A3; The BSP-A proteins from seminal plasma exhibit both simulatory and inhibitory actions on the release of pituitary gonadotropins. The exact function of these proteins is not known.
   
 
 0.819
ANG
Angiogenin-1; Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs) (By similarity). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. Has very low ribonucle [...]
      
 0.809
BSP5
Seminal plasma protein BSP-30 kDa; Binds to spermatozoa upon ejaculation and may play a role in sperm capacitation. Displays heparin-, gelatin- and phospholipid- binding activities; Belongs to the seminal plasma protein family.
   
 
 0.769
LOC100299268
Uncharacterized protein.
    
 
 0.757
DPM3
Dolichol-phosphate mannosyltransferase subunit 3; Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit DPM1 to the ER. Belongs to the DPM3 family.
      
 0.717
HHIPL2
HHIP like 2.
    
 
 0.707
RPS27A-2
Ubiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...]
    
 
 0.690
RPS27A
Ubiquitin-40S ribosomal protein S27a.
   
 
 0.677
LOC101903018
Acrosin inhibitor 1; Strong inhibitor of acrosin.
      
 0.665
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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