STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
P2RX4P2X purinoceptor 4; Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin (By similarity). (388 aa)    
Predicted Functional Partners:
P2RX7
P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family.
  
  
0.960
P2RX2
P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.
  
 
0.941
GRIN1
Glutamate ionotropic receptor NMDA type subunit 1.
   
 
 0.938
P2RX1
P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.
  
  
0.924
CHRNA7
Neuronal acetylcholine receptor subunit alpha-7; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
     
 0.906
GRIN2C
Glutamate ionotropic receptor NMDA type subunit 2C.
   
 
 0.901
GRIN2D
Glutamate ionotropic receptor NMDA type subunit 2D.
   
 
 0.901
P2RY2
P2Y purinoceptor 2; Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system.
      
 0.720
P2RX3
P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.
  
  
0.700
P2RX6
P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel.
  
  
0.699
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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