node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COPS7B | EPB41L4A | ENSBTAP00000062473 | ENSBTAP00000061587 | COP9 signalosome complex subunit 7b; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-de [...] | Erythrocyte membrane protein band 4.1 like 4A. | 0.541 |
COPS7B | PLCXD3 | ENSBTAP00000062473 | ENSBTAP00000014357 | COP9 signalosome complex subunit 7b; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-de [...] | PI-PLC X domain-containing protein 3. | 0.541 |
COPS7B | SNX29 | ENSBTAP00000062473 | ENSBTAP00000062382 | COP9 signalosome complex subunit 7b; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-de [...] | Sorting nexin-29; Belongs to the sorting nexin family. | 0.528 |
COPS7B | TMEM108 | ENSBTAP00000062473 | ENSBTAP00000024636 | COP9 signalosome complex subunit 7b; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-de [...] | Transmembrane protein 108; Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is necessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrit [...] | 0.572 |
COPS7B | VPS45 | ENSBTAP00000062473 | ENSBTAP00000027499 | COP9 signalosome complex subunit 7b; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-de [...] | Vacuolar protein sorting 45 homolog; Belongs to the STXBP/unc-18/SEC1 family. | 0.522 |
COPS7B | WDR64 | ENSBTAP00000062473 | ENSBTAP00000034065 | COP9 signalosome complex subunit 7b; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-de [...] | WD repeat domain 64. | 0.661 |
DIP2C | PLCXD3 | ENSBTAP00000015282 | ENSBTAP00000014357 | Disco interacting protein 2 homolog C. | PI-PLC X domain-containing protein 3. | 0.644 |
EPB41L4A | COPS7B | ENSBTAP00000061587 | ENSBTAP00000062473 | Erythrocyte membrane protein band 4.1 like 4A. | COP9 signalosome complex subunit 7b; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-de [...] | 0.541 |
EPB41L4A | PLCXD3 | ENSBTAP00000061587 | ENSBTAP00000014357 | Erythrocyte membrane protein band 4.1 like 4A. | PI-PLC X domain-containing protein 3. | 0.510 |
EPB41L4A | SNX29 | ENSBTAP00000061587 | ENSBTAP00000062382 | Erythrocyte membrane protein band 4.1 like 4A. | Sorting nexin-29; Belongs to the sorting nexin family. | 0.500 |
EPB41L4A | TMEM108 | ENSBTAP00000061587 | ENSBTAP00000024636 | Erythrocyte membrane protein band 4.1 like 4A. | Transmembrane protein 108; Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is necessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrit [...] | 0.542 |
EPB41L4A | VPS45 | ENSBTAP00000061587 | ENSBTAP00000027499 | Erythrocyte membrane protein band 4.1 like 4A. | Vacuolar protein sorting 45 homolog; Belongs to the STXBP/unc-18/SEC1 family. | 0.503 |
EPB41L4A | WDR64 | ENSBTAP00000061587 | ENSBTAP00000034065 | Erythrocyte membrane protein band 4.1 like 4A. | WD repeat domain 64. | 0.620 |
FYB1 | PLCXD3 | ENSBTAP00000001953 | ENSBTAP00000014357 | FYN binding protein 1. | PI-PLC X domain-containing protein 3. | 0.533 |
FYB1 | WDR64 | ENSBTAP00000001953 | ENSBTAP00000034065 | FYN binding protein 1. | WD repeat domain 64. | 0.482 |
PLCXD3 | COPS7B | ENSBTAP00000014357 | ENSBTAP00000062473 | PI-PLC X domain-containing protein 3. | COP9 signalosome complex subunit 7b; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-de [...] | 0.541 |
PLCXD3 | DIP2C | ENSBTAP00000014357 | ENSBTAP00000015282 | PI-PLC X domain-containing protein 3. | Disco interacting protein 2 homolog C. | 0.644 |
PLCXD3 | EPB41L4A | ENSBTAP00000014357 | ENSBTAP00000061587 | PI-PLC X domain-containing protein 3. | Erythrocyte membrane protein band 4.1 like 4A. | 0.510 |
PLCXD3 | FYB1 | ENSBTAP00000014357 | ENSBTAP00000001953 | PI-PLC X domain-containing protein 3. | FYN binding protein 1. | 0.533 |
PLCXD3 | SNX29 | ENSBTAP00000014357 | ENSBTAP00000062382 | PI-PLC X domain-containing protein 3. | Sorting nexin-29; Belongs to the sorting nexin family. | 0.495 |