node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BMP4 | FOXD3 | ENSBTAP00000004992 | ENSBTAP00000011206 | Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). | Forkhead box D3. | 0.444 |
BMP4 | LEF1 | ENSBTAP00000004992 | ENSBTAP00000061494 | Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). | Lymphoid enhancer binding factor 1. | 0.786 |
BMP4 | MSX1 | ENSBTAP00000004992 | ENSBTAP00000014447 | Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). | Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). | 0.763 |
BMP4 | MSX2 | ENSBTAP00000004992 | ENSBTAP00000018417 | Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). | Homeobox protein MSX-2; Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity). | 0.731 |
BMP4 | PAX9 | ENSBTAP00000004992 | ENSBTAP00000012105 | Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). | Paired box 9. | 0.609 |
BMP4 | SNAI2 | ENSBTAP00000004992 | ENSBTAP00000017600 | Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). | Zinc finger protein SNAI2; Transcriptional repressor that modulates both activator- dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of [...] | 0.556 |
BMP4 | TFAP2A | ENSBTAP00000004992 | ENSBTAP00000073737 | Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). | Transcription factor AP-2-alpha; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 [...] | 0.527 |
E2F4 | LEF1 | ENSBTAP00000015999 | ENSBTAP00000061494 | E2F transcription factor 4. | Lymphoid enhancer binding factor 1. | 0.438 |
E2F4 | MSX1 | ENSBTAP00000015999 | ENSBTAP00000014447 | E2F transcription factor 4. | Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). | 0.745 |
FOXD3 | BMP4 | ENSBTAP00000011206 | ENSBTAP00000004992 | Forkhead box D3. | Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). | 0.444 |
FOXD3 | LEF1 | ENSBTAP00000011206 | ENSBTAP00000061494 | Forkhead box D3. | Lymphoid enhancer binding factor 1. | 0.430 |
FOXD3 | MSX1 | ENSBTAP00000011206 | ENSBTAP00000014447 | Forkhead box D3. | Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). | 0.702 |
FOXD3 | MSX2 | ENSBTAP00000011206 | ENSBTAP00000018417 | Forkhead box D3. | Homeobox protein MSX-2; Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity). | 0.449 |
FOXD3 | SNAI2 | ENSBTAP00000011206 | ENSBTAP00000017600 | Forkhead box D3. | Zinc finger protein SNAI2; Transcriptional repressor that modulates both activator- dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of [...] | 0.606 |
FOXD3 | TFAP2A | ENSBTAP00000011206 | ENSBTAP00000073737 | Forkhead box D3. | Transcription factor AP-2-alpha; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 [...] | 0.585 |
LEF1 | BMP4 | ENSBTAP00000061494 | ENSBTAP00000004992 | Lymphoid enhancer binding factor 1. | Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). | 0.786 |
LEF1 | E2F4 | ENSBTAP00000061494 | ENSBTAP00000015999 | Lymphoid enhancer binding factor 1. | E2F transcription factor 4. | 0.438 |
LEF1 | FOXD3 | ENSBTAP00000061494 | ENSBTAP00000011206 | Lymphoid enhancer binding factor 1. | Forkhead box D3. | 0.430 |
LEF1 | MSX1 | ENSBTAP00000061494 | ENSBTAP00000014447 | Lymphoid enhancer binding factor 1. | Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). | 0.718 |
LEF1 | MSX2 | ENSBTAP00000061494 | ENSBTAP00000018417 | Lymphoid enhancer binding factor 1. | Homeobox protein MSX-2; Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity). | 0.647 |