| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EIF1AX | MRPL21 | ENSBTAP00000023455 | ENSBTAP00000005688 | Eukaryotic translation initiation factor 1A, X-linked; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. | 39S ribosomal protein L21, mitochondrial; Belongs to the bacterial ribosomal protein bL21 family. | 0.923 |
| EIF1AX | MRPS6 | ENSBTAP00000023455 | ENSBTAP00000059477 | Eukaryotic translation initiation factor 1A, X-linked; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. | 28S ribosomal protein S6, mitochondrial; Belongs to the bacterial ribosomal protein bS6 family. | 0.947 |
| EIF1AX | SSBP1 | ENSBTAP00000023455 | ENSBTAP00000014520 | Eukaryotic translation initiation factor 1A, X-linked; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. | Single-stranded DNA-binding protein, mitochondrial; Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5 [...] | 0.826 |
| MRPL21 | EIF1AX | ENSBTAP00000005688 | ENSBTAP00000023455 | 39S ribosomal protein L21, mitochondrial; Belongs to the bacterial ribosomal protein bL21 family. | Eukaryotic translation initiation factor 1A, X-linked; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. | 0.923 |
| MRPL21 | MRPL35 | ENSBTAP00000005688 | ENSBTAP00000006331 | 39S ribosomal protein L21, mitochondrial; Belongs to the bacterial ribosomal protein bL21 family. | 39S ribosomal protein L35, mitochondrial. | 0.853 |
| MRPL21 | MRPS6 | ENSBTAP00000005688 | ENSBTAP00000059477 | 39S ribosomal protein L21, mitochondrial; Belongs to the bacterial ribosomal protein bL21 family. | 28S ribosomal protein S6, mitochondrial; Belongs to the bacterial ribosomal protein bS6 family. | 0.998 |
| MRPL21 | SSBP1 | ENSBTAP00000005688 | ENSBTAP00000014520 | 39S ribosomal protein L21, mitochondrial; Belongs to the bacterial ribosomal protein bL21 family. | Single-stranded DNA-binding protein, mitochondrial; Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5 [...] | 0.887 |
| MRPL35 | MRPL21 | ENSBTAP00000006331 | ENSBTAP00000005688 | 39S ribosomal protein L35, mitochondrial. | 39S ribosomal protein L21, mitochondrial; Belongs to the bacterial ribosomal protein bL21 family. | 0.853 |
| MRPL35 | MRPS6 | ENSBTAP00000006331 | ENSBTAP00000059477 | 39S ribosomal protein L35, mitochondrial. | 28S ribosomal protein S6, mitochondrial; Belongs to the bacterial ribosomal protein bS6 family. | 0.802 |
| MRPL35 | SSBP1 | ENSBTAP00000006331 | ENSBTAP00000014520 | 39S ribosomal protein L35, mitochondrial. | Single-stranded DNA-binding protein, mitochondrial; Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5 [...] | 0.833 |
| MRPL35 | TMEM126A | ENSBTAP00000006331 | ENSBTAP00000000576 | 39S ribosomal protein L35, mitochondrial. | Transmembrane protein 126A. | 0.670 |
| MRPS6 | EIF1AX | ENSBTAP00000059477 | ENSBTAP00000023455 | 28S ribosomal protein S6, mitochondrial; Belongs to the bacterial ribosomal protein bS6 family. | Eukaryotic translation initiation factor 1A, X-linked; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. | 0.947 |
| MRPS6 | MRPL21 | ENSBTAP00000059477 | ENSBTAP00000005688 | 28S ribosomal protein S6, mitochondrial; Belongs to the bacterial ribosomal protein bS6 family. | 39S ribosomal protein L21, mitochondrial; Belongs to the bacterial ribosomal protein bL21 family. | 0.998 |
| MRPS6 | MRPL35 | ENSBTAP00000059477 | ENSBTAP00000006331 | 28S ribosomal protein S6, mitochondrial; Belongs to the bacterial ribosomal protein bS6 family. | 39S ribosomal protein L35, mitochondrial. | 0.802 |
| MRPS6 | SSBP1 | ENSBTAP00000059477 | ENSBTAP00000014520 | 28S ribosomal protein S6, mitochondrial; Belongs to the bacterial ribosomal protein bS6 family. | Single-stranded DNA-binding protein, mitochondrial; Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5 [...] | 0.945 |
| POLG2 | POLRMT | ENSBTAP00000024509 | ENSBTAP00000020034 | DNA polymerase subunit gamma-2, mitochondrial; Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA (By similarity). | DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family. | 0.763 |
| POLG2 | RNASEH1 | ENSBTAP00000024509 | ENSBTAP00000063545 | DNA polymerase subunit gamma-2, mitochondrial; Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA (By similarity). | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.632 |
| POLG2 | SSBP1 | ENSBTAP00000024509 | ENSBTAP00000014520 | DNA polymerase subunit gamma-2, mitochondrial; Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA (By similarity). | Single-stranded DNA-binding protein, mitochondrial; Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5 [...] | 0.797 |
| POLG2 | TFAM | ENSBTAP00000024509 | ENSBTAP00000052192 | DNA polymerase subunit gamma-2, mitochondrial; Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA (By similarity). | Transcription factor A, mitochondrial; Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymeras [...] | 0.756 |
| POLRMT | POLG2 | ENSBTAP00000020034 | ENSBTAP00000024509 | DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family. | DNA polymerase subunit gamma-2, mitochondrial; Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA (By similarity). | 0.763 |
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