node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKT3 | EGFR | ENSBTAP00000023654 | ENSBTAP00000070620 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Receptor protein-tyrosine kinase. | 0.400 |
AKT3 | PIK3CA | ENSBTAP00000023654 | ENSBTAP00000068953 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to v [...] | 0.988 |
AKT3 | PIK3CB | ENSBTAP00000023654 | ENSBTAP00000009083 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. | 0.970 |
AKT3 | PIK3CD | ENSBTAP00000023654 | ENSBTAP00000064363 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.934 |
AKT3 | PIK3CG | ENSBTAP00000023654 | ENSBTAP00000064044 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. | 0.975 |
AKT3 | PIK3R1 | ENSBTAP00000023654 | ENSBTAP00000014594 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] | 0.984 |
AKT3 | PIK3R2 | ENSBTAP00000023654 | ENSBTAP00000003033 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Phosphatidylinositol 3-kinase regulatory subunit beta; Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein- tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating t [...] | 0.964 |
AKT3 | PIK3R3 | ENSBTAP00000023654 | ENSBTAP00000003878 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Phosphatidylinositol 3-kinase regulatory subunit gamma; Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. | 0.952 |
CBL | EGFR | ENSBTAP00000061310 | ENSBTAP00000070620 | Cbl proto-oncogene. | Receptor protein-tyrosine kinase. | 0.999 |
CBL | PDGFRB | ENSBTAP00000061310 | ENSBTAP00000064374 | Cbl proto-oncogene. | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. | 0.416 |
CBL | PIK3CA | ENSBTAP00000061310 | ENSBTAP00000068953 | Cbl proto-oncogene. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to v [...] | 0.781 |
CBL | PIK3CB | ENSBTAP00000061310 | ENSBTAP00000009083 | Cbl proto-oncogene. | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. | 0.761 |
CBL | PIK3CD | ENSBTAP00000061310 | ENSBTAP00000064363 | Cbl proto-oncogene. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.692 |
CBL | PIK3R1 | ENSBTAP00000061310 | ENSBTAP00000014594 | Cbl proto-oncogene. | Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] | 0.987 |
CBL | PIK3R2 | ENSBTAP00000061310 | ENSBTAP00000003033 | Cbl proto-oncogene. | Phosphatidylinositol 3-kinase regulatory subunit beta; Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein- tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating t [...] | 0.873 |
CBL | PIK3R3 | ENSBTAP00000061310 | ENSBTAP00000003878 | Cbl proto-oncogene. | Phosphatidylinositol 3-kinase regulatory subunit gamma; Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. | 0.827 |
EGFR | AKT3 | ENSBTAP00000070620 | ENSBTAP00000023654 | Receptor protein-tyrosine kinase. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.400 |
EGFR | CBL | ENSBTAP00000070620 | ENSBTAP00000061310 | Receptor protein-tyrosine kinase. | Cbl proto-oncogene. | 0.999 |
EGFR | PDGFRB | ENSBTAP00000070620 | ENSBTAP00000064374 | Receptor protein-tyrosine kinase. | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. | 0.977 |
EGFR | PIK3CA | ENSBTAP00000070620 | ENSBTAP00000068953 | Receptor protein-tyrosine kinase. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to v [...] | 0.994 |