| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARMC6 | KLHDC4 | ENSBTAP00000069861 | ENSBTAP00000009093 | Armadillo repeat containing 6. | Kelch domain containing 4. | 0.788 |
| ARMC6 | PRND | ENSBTAP00000069861 | ENSBTAP00000014624 | Armadillo repeat containing 6. | Prion-like protein doppel; Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (By similarity). Belongs to the prion family. | 0.601 |
| CCER2 | PRND | ENSBTAP00000055491 | ENSBTAP00000014624 | Coiled-coil glutamate rich protein 2. | Prion-like protein doppel; Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (By similarity). Belongs to the prion family. | 0.563 |
| KLHDC4 | ARMC6 | ENSBTAP00000009093 | ENSBTAP00000069861 | Kelch domain containing 4. | Armadillo repeat containing 6. | 0.788 |
| KLHDC4 | PRND | ENSBTAP00000009093 | ENSBTAP00000014624 | Kelch domain containing 4. | Prion-like protein doppel; Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (By similarity). Belongs to the prion family. | 0.575 |
| MTG1 | PRND | ENSBTAP00000027058 | ENSBTAP00000014624 | Mitochondrial ribosome-associated GTPase 1; Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity (By similarity). Displays mitochondrial GTPase activity (By similarity). | Prion-like protein doppel; Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (By similarity). Belongs to the prion family. | 0.597 |
| PIGK | PRND | ENSBTAP00000041428 | ENSBTAP00000014624 | GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein (By similarity). | Prion-like protein doppel; Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (By similarity). Belongs to the prion family. | 0.579 |
| PIGK | SPATA6 | ENSBTAP00000041428 | ENSBTAP00000004068 | GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein (By similarity). | Spermatogenesis-associated protein 6; Required for formation of the sperm connecting piece during spermiogenesis. Sperm connecting piece is essential for linking the developing flagellum to the head during late spermiogenesis. May be involved in myosin-based microfilament transport through interaction with myosin subunits. | 0.572 |
| PIGK | SUOX | ENSBTAP00000041428 | ENSBTAP00000008101 | GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein (By similarity). | Sulfite oxidase. | 0.427 |
| PRND | ARMC6 | ENSBTAP00000014624 | ENSBTAP00000069861 | Prion-like protein doppel; Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (By similarity). Belongs to the prion family. | Armadillo repeat containing 6. | 0.601 |
| PRND | CCER2 | ENSBTAP00000014624 | ENSBTAP00000055491 | Prion-like protein doppel; Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (By similarity). Belongs to the prion family. | Coiled-coil glutamate rich protein 2. | 0.563 |
| PRND | KLHDC4 | ENSBTAP00000014624 | ENSBTAP00000009093 | Prion-like protein doppel; Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (By similarity). Belongs to the prion family. | Kelch domain containing 4. | 0.575 |
| PRND | MTG1 | ENSBTAP00000014624 | ENSBTAP00000027058 | Prion-like protein doppel; Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (By similarity). Belongs to the prion family. | Mitochondrial ribosome-associated GTPase 1; Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity (By similarity). Displays mitochondrial GTPase activity (By similarity). | 0.597 |
| PRND | PIGK | ENSBTAP00000014624 | ENSBTAP00000041428 | Prion-like protein doppel; Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (By similarity). Belongs to the prion family. | GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein (By similarity). | 0.579 |
| PRND | PRNP | ENSBTAP00000014624 | ENSBTAP00000069134 | Prion-like protein doppel; Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (By similarity). Belongs to the prion family. | Major prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase deg [...] | 0.828 |
| PRND | RASSF2 | ENSBTAP00000014624 | ENSBTAP00000023060 | Prion-like protein doppel; Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (By similarity). Belongs to the prion family. | Ras association domain family member 2. | 0.606 |
| PRND | SPATA6 | ENSBTAP00000014624 | ENSBTAP00000004068 | Prion-like protein doppel; Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (By similarity). Belongs to the prion family. | Spermatogenesis-associated protein 6; Required for formation of the sperm connecting piece during spermiogenesis. Sperm connecting piece is essential for linking the developing flagellum to the head during late spermiogenesis. May be involved in myosin-based microfilament transport through interaction with myosin subunits. | 0.623 |
| PRND | SPRN | ENSBTAP00000014624 | ENSBTAP00000054072 | Prion-like protein doppel; Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (By similarity). Belongs to the prion family. | Shadow of prion protein; Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity); Belongs to the SPRN family. | 0.744 |
| PRND | SUOX | ENSBTAP00000014624 | ENSBTAP00000008101 | Prion-like protein doppel; Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (By similarity). Belongs to the prion family. | Sulfite oxidase. | 0.559 |
| PRNP | PRND | ENSBTAP00000069134 | ENSBTAP00000014624 | Major prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase deg [...] | Prion-like protein doppel; Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) (By similarity). Belongs to the prion family. | 0.828 |