node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CGRRF1 | RNF13 | ENSBTAP00000022778 | ENSBTAP00000014803 | Cell growth regulator with ring finger domain 1. | E3 ubiquitin-protein ligase RNF13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA. | 0.689 |
CGRRF1 | RNF170 | ENSBTAP00000022778 | ENSBTAP00000072624 | Cell growth regulator with ring finger domain 1. | E3 ubiquitin-protein ligase RNF170; E3 ubiquitin-protein ligase. Plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells. | 0.840 |
CGRRF1 | RNF185 | ENSBTAP00000022778 | ENSBTAP00000003661 | Cell growth regulator with ring finger domain 1. | Ring finger protein 185. | 0.646 |
CGRRF1 | RNF5 | ENSBTAP00000022778 | ENSBTAP00000067111 | Cell growth regulator with ring finger domain 1. | Ring finger protein 5. | 0.593 |
CGRRF1 | RNFT1 | ENSBTAP00000022778 | ENSBTAP00000053847 | Cell growth regulator with ring finger domain 1. | Ring finger protein, transmembrane 1. | 0.702 |
RNF13 | CGRRF1 | ENSBTAP00000014803 | ENSBTAP00000022778 | E3 ubiquitin-protein ligase RNF13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA. | Cell growth regulator with ring finger domain 1. | 0.689 |
RNF13 | RNF170 | ENSBTAP00000014803 | ENSBTAP00000072624 | E3 ubiquitin-protein ligase RNF13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA. | E3 ubiquitin-protein ligase RNF170; E3 ubiquitin-protein ligase. Plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells. | 0.672 |
RNF13 | RNF185 | ENSBTAP00000014803 | ENSBTAP00000003661 | E3 ubiquitin-protein ligase RNF13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA. | Ring finger protein 185. | 0.601 |
RNF13 | RNF5 | ENSBTAP00000014803 | ENSBTAP00000067111 | E3 ubiquitin-protein ligase RNF13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA. | Ring finger protein 5. | 0.543 |
RNF13 | RNFT1 | ENSBTAP00000014803 | ENSBTAP00000053847 | E3 ubiquitin-protein ligase RNF13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA. | Ring finger protein, transmembrane 1. | 0.682 |
RNF13 | SERTAD3 | ENSBTAP00000014803 | ENSBTAP00000013876 | E3 ubiquitin-protein ligase RNF13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA. | SERTA domain containing 3. | 0.548 |
RNF13 | SNAPIN | ENSBTAP00000014803 | ENSBTAP00000016548 | E3 ubiquitin-protein ligase RNF13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA. | SNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] | 0.566 |
RNF13 | TRIM59 | ENSBTAP00000014803 | ENSBTAP00000010623 | E3 ubiquitin-protein ligase RNF13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA. | Tripartite motif containing 59. | 0.574 |
RNF13 | WDR48 | ENSBTAP00000014803 | ENSBTAP00000004876 | E3 ubiquitin-protein ligase RNF13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA. | WD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes; Belongs to the WD repeat WDR48 family. | 0.566 |
RNF13 | ZGPAT | ENSBTAP00000014803 | ENSBTAP00000009860 | E3 ubiquitin-protein ligase RNF13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA. | Zinc finger CCCH-type with G patch domain-containing protein; Transcription repressor that specifically binds the 5'- GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor (By similarity). | 0.551 |
RNF170 | CGRRF1 | ENSBTAP00000072624 | ENSBTAP00000022778 | E3 ubiquitin-protein ligase RNF170; E3 ubiquitin-protein ligase. Plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells. | Cell growth regulator with ring finger domain 1. | 0.840 |
RNF170 | RNF13 | ENSBTAP00000072624 | ENSBTAP00000014803 | E3 ubiquitin-protein ligase RNF170; E3 ubiquitin-protein ligase. Plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells. | E3 ubiquitin-protein ligase RNF13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA. | 0.672 |
RNF170 | RNF185 | ENSBTAP00000072624 | ENSBTAP00000003661 | E3 ubiquitin-protein ligase RNF170; E3 ubiquitin-protein ligase. Plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells. | Ring finger protein 185. | 0.636 |
RNF170 | RNF5 | ENSBTAP00000072624 | ENSBTAP00000067111 | E3 ubiquitin-protein ligase RNF170; E3 ubiquitin-protein ligase. Plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells. | Ring finger protein 5. | 0.652 |
RNF170 | RNFT1 | ENSBTAP00000072624 | ENSBTAP00000053847 | E3 ubiquitin-protein ligase RNF170; E3 ubiquitin-protein ligase. Plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells. | Ring finger protein, transmembrane 1. | 0.740 |