node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACSL4 | FTH1 | ENSBTAP00000050572 | ENSBTAP00000064784 | Acyl-CoA synthetase long chain family member 4. | Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. | 0.695 |
ACSL4 | FTL | ENSBTAP00000050572 | ENSBTAP00000009965 | Acyl-CoA synthetase long chain family member 4. | Ferritin light chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity); Belongs to the ferritin family. | 0.502 |
ACSL4 | GPX4 | ENSBTAP00000050572 | ENSBTAP00000067758 | Acyl-CoA synthetase long chain family member 4. | Phospholipid hydroperoxide glutathione peroxidase; Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation. Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron- dependent accumulation of lipid reactive oxygen species. The presence of s [...] | 0.866 |
ACSL4 | LOC783993 | ENSBTAP00000050572 | ENSBTAP00000052216 | Acyl-CoA synthetase long chain family member 4. | Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. | 0.484 |
ACSL4 | LOC788801 | ENSBTAP00000050572 | ENSBTAP00000072850 | Acyl-CoA synthetase long chain family member 4. | Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. | 0.484 |
ACSL4 | NCOA4 | ENSBTAP00000050572 | ENSBTAP00000066213 | Acyl-CoA synthetase long chain family member 4. | Nuclear receptor coactivator 4. | 0.582 |
ACSL4 | SLC7A11 | ENSBTAP00000050572 | ENSBTAP00000055608 | Acyl-CoA synthetase long chain family member 4. | Solute carrier family 7 member 11. | 0.801 |
ACSL4 | TFRC | ENSBTAP00000050572 | ENSBTAP00000043726 | Acyl-CoA synthetase long chain family member 4. | Transferrin receptor. | 0.635 |
FTH1 | ACSL4 | ENSBTAP00000064784 | ENSBTAP00000050572 | Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. | Acyl-CoA synthetase long chain family member 4. | 0.695 |
FTH1 | FTL | ENSBTAP00000064784 | ENSBTAP00000009965 | Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. | Ferritin light chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity); Belongs to the ferritin family. | 0.994 |
FTH1 | GPX4 | ENSBTAP00000064784 | ENSBTAP00000067758 | Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. | Phospholipid hydroperoxide glutathione peroxidase; Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation. Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron- dependent accumulation of lipid reactive oxygen species. The presence of s [...] | 0.798 |
FTH1 | LOC783993 | ENSBTAP00000064784 | ENSBTAP00000052216 | Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. | Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. | 0.877 |
FTH1 | LOC788801 | ENSBTAP00000064784 | ENSBTAP00000072850 | Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. | Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. | 0.879 |
FTH1 | NCOA4 | ENSBTAP00000064784 | ENSBTAP00000066213 | Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. | Nuclear receptor coactivator 4. | 0.817 |
FTH1 | NQO1 | ENSBTAP00000064784 | ENSBTAP00000071181 | Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. | NAD(P)H quinone dehydrogenase 1. | 0.658 |
FTH1 | SLC40A1 | ENSBTAP00000064784 | ENSBTAP00000045304 | Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. | Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. | 0.720 |
FTH1 | SLC7A11 | ENSBTAP00000064784 | ENSBTAP00000055608 | Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. | Solute carrier family 7 member 11. | 0.626 |
FTH1 | TFRC | ENSBTAP00000064784 | ENSBTAP00000043726 | Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. | Transferrin receptor. | 0.778 |
FTL | ACSL4 | ENSBTAP00000009965 | ENSBTAP00000050572 | Ferritin light chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity); Belongs to the ferritin family. | Acyl-CoA synthetase long chain family member 4. | 0.502 |
FTL | FTH1 | ENSBTAP00000009965 | ENSBTAP00000064784 | Ferritin light chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity); Belongs to the ferritin family. | Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. | 0.994 |