node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BIRC3 | IER3 | ENSBTAP00000034604 | ENSBTAP00000015092 | Baculoviral IAP repeat-containing 3. | Immediate early response 3. | 0.584 |
BIRC3 | NFKBIA | ENSBTAP00000034604 | ENSBTAP00000022183 | Baculoviral IAP repeat-containing 3. | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha. | 0.688 |
BIRC3 | NFKBIZ | ENSBTAP00000034604 | ENSBTAP00000014591 | Baculoviral IAP repeat-containing 3. | NF-kappa-B inhibitor zeta; Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promote [...] | 0.633 |
BIRC3 | TNFAIP3 | ENSBTAP00000034604 | ENSBTAP00000072859 | Baculoviral IAP repeat-containing 3. | TNF alpha induced protein 3. | 0.887 |
IER2 | IER3 | ENSBTAP00000021755 | ENSBTAP00000015092 | Immediate early response 2. | Immediate early response 3. | 0.622 |
IER3 | BIRC3 | ENSBTAP00000015092 | ENSBTAP00000034604 | Immediate early response 3. | Baculoviral IAP repeat-containing 3. | 0.584 |
IER3 | IER2 | ENSBTAP00000015092 | ENSBTAP00000021755 | Immediate early response 3. | Immediate early response 2. | 0.622 |
IER3 | MAPK1 | ENSBTAP00000015092 | ENSBTAP00000013623 | Immediate early response 3. | Mitogen-activated protein kinase 1; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] | 0.587 |
IER3 | MAPK3 | ENSBTAP00000015092 | ENSBTAP00000021507 | Immediate early response 3. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.587 |
IER3 | NFKBIA | ENSBTAP00000015092 | ENSBTAP00000022183 | Immediate early response 3. | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha. | 0.599 |
IER3 | NFKBIZ | ENSBTAP00000015092 | ENSBTAP00000014591 | Immediate early response 3. | NF-kappa-B inhibitor zeta; Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promote [...] | 0.596 |
IER3 | PPP2R5B | ENSBTAP00000015092 | ENSBTAP00000009284 | Immediate early response 3. | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. | 0.627 |
IER3 | PPP2R5C | ENSBTAP00000015092 | ENSBTAP00000072851 | Immediate early response 3. | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. | 0.628 |
IER3 | TNFAIP3 | ENSBTAP00000015092 | ENSBTAP00000072859 | Immediate early response 3. | TNF alpha induced protein 3. | 0.600 |
IER3 | ZFP36 | ENSBTAP00000015092 | ENSBTAP00000055077 | Immediate early response 3. | mRNA decay activator protein ZFP36; Zinc-finger RNA-binding protein that destabilizes numerous cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as an 3'- untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation. Functions also by recruiting compo [...] | 0.704 |
MAPK1 | IER3 | ENSBTAP00000013623 | ENSBTAP00000015092 | Mitogen-activated protein kinase 1; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] | Immediate early response 3. | 0.587 |
MAPK1 | MAPK3 | ENSBTAP00000013623 | ENSBTAP00000021507 | Mitogen-activated protein kinase 1; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.902 |
MAPK1 | PPP2R5B | ENSBTAP00000013623 | ENSBTAP00000009284 | Mitogen-activated protein kinase 1; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. | 0.567 |
MAPK1 | PPP2R5C | ENSBTAP00000013623 | ENSBTAP00000072851 | Mitogen-activated protein kinase 1; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. | 0.538 |
MAPK3 | IER3 | ENSBTAP00000021507 | ENSBTAP00000015092 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | Immediate early response 3. | 0.587 |