STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TRPC2Short transient receptor potential channel 2 homolog; Thought to form a receptor-activated calcium permeant cation channel; Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC2 sub-subfamily. (1262 aa)    
Predicted Functional Partners:
STIM1
Stromal interaction molecule 1; Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release- activated Ca(2+) (CRAC) channel subunit ORAI1. Involved in enamel formation. Activated following interaction with STIMATE, leading to promote STIM1 conformational switch.
    
 
 0.749
TRPV2
Transient receptor potential cation channel, subfamily V, member 2; Belongs to the transient receptor (TC 1.A.4) family.
      
 0.721
TRPM6-2
LSDAT_euk domain-containing protein.
    
 
 0.700
TRPV4
Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family.
      
 0.694
TRPA1
Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family.
   
  
 0.659
TRPV3
Transient receptor potential cation channel subfamily V member 3; Belongs to the transient receptor (TC 1.A.4) family.
      
 0.658
STIM2
Stromal interaction molecule 2.
    
 
 0.650
TRPV1
Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family.
      
 0.627
TRPM3
Transient receptor potential cation channel, subfamily M, member 3.
    
 
 0.617
TRPV5
Transient receptor potential cation channel subfamily V member 5; Belongs to the transient receptor (TC 1.A.4) family.
      
 0.615
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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