node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CYP19A1 | CYP3A4 | ENSBTAP00000019823 | ENSBTAP00000007170 | Aromatase; A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19- aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19 [...] | Uncharacterized protein. | 0.949 |
CYP19A1 | CYP3A5 | ENSBTAP00000019823 | ENSBTAP00000016177 | Aromatase; A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19- aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19 [...] | Cytochrome P450 3A28; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.951 |
CYP19A1 | HSD17B1 | ENSBTAP00000019823 | ENSBTAP00000054286 | Aromatase; A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19- aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19 [...] | Hydroxysteroid (17-beta) dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.981 |
CYP19A1 | HSD17B2 | ENSBTAP00000019823 | ENSBTAP00000004193 | Aromatase; A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19- aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19 [...] | 17-beta hydroxysteroid dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.963 |
CYP19A1 | HSD17B7 | ENSBTAP00000019823 | ENSBTAP00000007841 | Aromatase; A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19- aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19 [...] | Hydroxysteroid 17-beta dehydrogenase 7. | 0.961 |
CYP19A1 | LOC615303 | ENSBTAP00000019823 | ENSBTAP00000004581 | Aromatase; A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19- aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19 [...] | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.932 |
CYP19A1 | SULT1E1 | ENSBTAP00000019823 | ENSBTAP00000015862 | Aromatase; A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19- aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19 [...] | Sulfotransferase 1E1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (By similarity). Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency. Does not sulfonate cortisol, testosterone and dopamine (By similarity). | 0.965 |
CYP19A1 | UGT1A1 | ENSBTAP00000019823 | ENSBTAP00000036928 | Aromatase; A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19- aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19 [...] | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.937 |
CYP19A1 | UGT2A1 | ENSBTAP00000019823 | ENSBTAP00000051040 | Aromatase; A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19- aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19 [...] | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.938 |
CYP19A1 | UGT2B10 | ENSBTAP00000019823 | ENSBTAP00000022664 | Aromatase; A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19- aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19 [...] | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.934 |
CYP3A4 | CYP19A1 | ENSBTAP00000007170 | ENSBTAP00000019823 | Uncharacterized protein. | Aromatase; A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19- aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19 [...] | 0.949 |
CYP3A4 | CYP3A5 | ENSBTAP00000007170 | ENSBTAP00000016177 | Uncharacterized protein. | Cytochrome P450 3A28; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. | 0.407 |
CYP3A4 | HSD17B1 | ENSBTAP00000007170 | ENSBTAP00000054286 | Uncharacterized protein. | Hydroxysteroid (17-beta) dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.704 |
CYP3A4 | HSD17B2 | ENSBTAP00000007170 | ENSBTAP00000004193 | Uncharacterized protein. | 17-beta hydroxysteroid dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.690 |
CYP3A4 | HSD17B7 | ENSBTAP00000007170 | ENSBTAP00000007841 | Uncharacterized protein. | Hydroxysteroid 17-beta dehydrogenase 7. | 0.710 |
CYP3A4 | LOC615303 | ENSBTAP00000007170 | ENSBTAP00000004581 | Uncharacterized protein. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.904 |
CYP3A4 | SULT1E1 | ENSBTAP00000007170 | ENSBTAP00000015862 | Uncharacterized protein. | Sulfotransferase 1E1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (By similarity). Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency. Does not sulfonate cortisol, testosterone and dopamine (By similarity). | 0.933 |
CYP3A4 | UGT1A1 | ENSBTAP00000007170 | ENSBTAP00000036928 | Uncharacterized protein. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.933 |
CYP3A4 | UGT2A1 | ENSBTAP00000007170 | ENSBTAP00000051040 | Uncharacterized protein. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.904 |
CYP3A4 | UGT2B10 | ENSBTAP00000007170 | ENSBTAP00000022664 | Uncharacterized protein. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.922 |