| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CUL5 | ELOC | ENSBTAP00000060422 | ENSBTAP00000065112 | Cullin 5; Belongs to the cullin family. | Elongin-C; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an [...] | 0.999 |
| CUL5 | JAK2 | ENSBTAP00000060422 | ENSBTAP00000015986 | Cullin 5; Belongs to the cullin family. | Tyrosine-protein kinase. | 0.676 |
| CUL5 | SOCS1 | ENSBTAP00000060422 | ENSBTAP00000005753 | Cullin 5; Belongs to the cullin family. | Suppressor of cytokine signaling 1. | 0.874 |
| CUL5 | SOCS2 | ENSBTAP00000060422 | ENSBTAP00000069411 | Cullin 5; Belongs to the cullin family. | Suppressor of cytokine signaling 2; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). | 0.981 |
| CUL5 | SOCS3 | ENSBTAP00000060422 | ENSBTAP00000011106 | Cullin 5; Belongs to the cullin family. | Suppressor of cytokine signaling 3; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin and leptin receptors. Inhibits JAK2 kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Proba [...] | 0.904 |
| ELOC | CUL5 | ENSBTAP00000065112 | ENSBTAP00000060422 | Elongin-C; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an [...] | Cullin 5; Belongs to the cullin family. | 0.999 |
| ELOC | JAK2 | ENSBTAP00000065112 | ENSBTAP00000015986 | Elongin-C; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an [...] | Tyrosine-protein kinase. | 0.653 |
| ELOC | SOCS1 | ENSBTAP00000065112 | ENSBTAP00000005753 | Elongin-C; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an [...] | Suppressor of cytokine signaling 1. | 0.919 |
| ELOC | SOCS2 | ENSBTAP00000065112 | ENSBTAP00000069411 | Elongin-C; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an [...] | Suppressor of cytokine signaling 2; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). | 0.932 |
| ELOC | SOCS3 | ENSBTAP00000065112 | ENSBTAP00000011106 | Elongin-C; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an [...] | Suppressor of cytokine signaling 3; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin and leptin receptors. Inhibits JAK2 kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Proba [...] | 0.831 |
| INSR | IRS1 | ENSBTAP00000016858 | ENSBTAP00000028392 | Tyrosine-protein kinase receptor. | Insulin receptor substrate 1. | 0.989 |
| INSR | IRS2 | ENSBTAP00000016858 | ENSBTAP00000049448 | Tyrosine-protein kinase receptor. | Insulin receptor substrate 2. | 0.986 |
| INSR | IRS4 | ENSBTAP00000016858 | ENSBTAP00000008574 | Tyrosine-protein kinase receptor. | Insulin receptor substrate 4. | 0.966 |
| INSR | LOC107131843 | ENSBTAP00000016858 | ENSBTAP00000055405 | Tyrosine-protein kinase receptor. | Uncharacterized protein. | 0.970 |
| INSR | SOCS1 | ENSBTAP00000016858 | ENSBTAP00000005753 | Tyrosine-protein kinase receptor. | Suppressor of cytokine signaling 1. | 0.953 |
| INSR | SOCS2 | ENSBTAP00000016858 | ENSBTAP00000069411 | Tyrosine-protein kinase receptor. | Suppressor of cytokine signaling 2; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). | 0.919 |
| INSR | SOCS3 | ENSBTAP00000016858 | ENSBTAP00000011106 | Tyrosine-protein kinase receptor. | Suppressor of cytokine signaling 3; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin and leptin receptors. Inhibits JAK2 kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Proba [...] | 0.962 |
| IRS1 | INSR | ENSBTAP00000028392 | ENSBTAP00000016858 | Insulin receptor substrate 1. | Tyrosine-protein kinase receptor. | 0.989 |
| IRS1 | IRS2 | ENSBTAP00000028392 | ENSBTAP00000049448 | Insulin receptor substrate 1. | Insulin receptor substrate 2. | 0.948 |
| IRS1 | IRS4 | ENSBTAP00000028392 | ENSBTAP00000008574 | Insulin receptor substrate 1. | Insulin receptor substrate 4. | 0.792 |