STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FOXA3Hepatocyte nuclear factor 3-gamma; Transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes (By similarity). (351 aa)    
Predicted Functional Partners:
HHEX
Hematopoietically expressed homeobox.
   
  
 0.757
SPDEF
SAM pointed domain containing ETS transcription factor.
   
  
 0.701
MYL7
Myosin light chain 7.
      
 0.665
GATA6
GATA binding protein 6.
   
 
 0.664
GATA4
GATA binding protein 4.
   
 
 0.649
TTR
Transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (By similarity). Belongs to the transthyretin family.
      
 0.595
HNF1A
HNF1 homeobox A.
   
  
 0.538
AFP
Alpha-fetoprotein; Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin.
    
 
 0.537
HNF4A
Hepatocyte nuclear factor 4 alpha.
   
 
 0.526
ATF5
Activating transcription factor 5.
    
 
 0.508
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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