node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAMTS13 | F10 | ENSBTAP00000020085 | ENSBTAP00000021789 | ADAM metallopeptidase with thrombospondin type 1 motif 13. | Activated factor Xa heavy chain; Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting; Belongs to the peptidase S1 family. | 0.446 |
ADAMTS13 | F8 | ENSBTAP00000020085 | ENSBTAP00000036581 | ADAM metallopeptidase with thrombospondin type 1 motif 13. | Coagulation factor VIII; Belongs to the multicopper oxidase family. | 0.619 |
ADAMTS13 | ITGAV | ENSBTAP00000020085 | ENSBTAP00000060618 | ADAM metallopeptidase with thrombospondin type 1 motif 13. | Integrin alpha-V heavy chain; The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase- 2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential [...] | 0.451 |
ADAMTS13 | ITGB3 | ENSBTAP00000020085 | ENSBTAP00000013173 | ADAM metallopeptidase with thrombospondin type 1 motif 13. | Integrin beta; Belongs to the integrin beta chain family. | 0.408 |
ADAMTS13 | SELP | ENSBTAP00000020085 | ENSBTAP00000027661 | ADAM metallopeptidase with thrombospondin type 1 motif 13. | P-selectin; Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG (By similarity). Belongs to the selectin/LECAM family. | 0.590 |
ADAMTS13 | VWF | ENSBTAP00000020085 | ENSBTAP00000016273 | ADAM metallopeptidase with thrombospondin type 1 motif 13. | Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. | 0.926 |
CD34 | ITGAV | ENSBTAP00000073399 | ENSBTAP00000060618 | CD34 molecule. | Integrin alpha-V heavy chain; The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase- 2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential [...] | 0.616 |
CD34 | ITGB3 | ENSBTAP00000073399 | ENSBTAP00000013173 | CD34 molecule. | Integrin beta; Belongs to the integrin beta chain family. | 0.441 |
CD34 | SELP | ENSBTAP00000073399 | ENSBTAP00000027661 | CD34 molecule. | P-selectin; Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG (By similarity). Belongs to the selectin/LECAM family. | 0.622 |
CD34 | VWF | ENSBTAP00000073399 | ENSBTAP00000016273 | CD34 molecule. | Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. | 0.935 |
F10 | ADAMTS13 | ENSBTAP00000021789 | ENSBTAP00000020085 | Activated factor Xa heavy chain; Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting; Belongs to the peptidase S1 family. | ADAM metallopeptidase with thrombospondin type 1 motif 13. | 0.446 |
F10 | F8 | ENSBTAP00000021789 | ENSBTAP00000036581 | Activated factor Xa heavy chain; Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting; Belongs to the peptidase S1 family. | Coagulation factor VIII; Belongs to the multicopper oxidase family. | 0.898 |
F10 | VWF | ENSBTAP00000021789 | ENSBTAP00000016273 | Activated factor Xa heavy chain; Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting; Belongs to the peptidase S1 family. | Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. | 0.932 |
F8 | ADAMTS13 | ENSBTAP00000036581 | ENSBTAP00000020085 | Coagulation factor VIII; Belongs to the multicopper oxidase family. | ADAM metallopeptidase with thrombospondin type 1 motif 13. | 0.619 |
F8 | F10 | ENSBTAP00000036581 | ENSBTAP00000021789 | Coagulation factor VIII; Belongs to the multicopper oxidase family. | Activated factor Xa heavy chain; Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting; Belongs to the peptidase S1 family. | 0.898 |
F8 | GP5 | ENSBTAP00000036581 | ENSBTAP00000017571 | Coagulation factor VIII; Belongs to the multicopper oxidase family. | Glycoprotein V platelet. | 0.527 |
F8 | GP9 | ENSBTAP00000036581 | ENSBTAP00000019525 | Coagulation factor VIII; Belongs to the multicopper oxidase family. | Glycoprotein IX platelet. | 0.572 |
F8 | VWF | ENSBTAP00000036581 | ENSBTAP00000016273 | Coagulation factor VIII; Belongs to the multicopper oxidase family. | Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. | 0.994 |
GP1BA | GP5 | ENSBTAP00000006460 | ENSBTAP00000017571 | Glycoprotein Ib platelet subunit alpha. | Glycoprotein V platelet. | 0.947 |
GP1BA | GP9 | ENSBTAP00000006460 | ENSBTAP00000019525 | Glycoprotein Ib platelet subunit alpha. | Glycoprotein IX platelet. | 0.994 |