Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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EDAEctodysplasin-A, membrane form; Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. Isoform A1 binds only to the receptor EDAR, while isoform A2 binds exclusively to the receptor EDA2R. May also play a role in cell adhesion. Isoform A2 binds exclusively to the receptor EDA2R. (261 aa)    
Predicted Functional Partners:
EDAR
Ectodysplasin A receptor.
     
 0.994
EDA2R
Ectodysplasin A2 receptor.
     
 0.929
LIG1
DNA ligase.
    
 0.878
EDARADD
EDAR associated death domain.
     
 0.785
MAP3K20
Uncharacterized protein.
    
 0.772
MAP3K7
Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...]
    
 0.772
MAP2K7
Mitogen-activated protein kinase kinase 7.
    
 
 0.747
MAPK10
Mitogen-activated protein kinase.
   
 0.731
MAPK9
Mitogen-activated protein kinase.
   
 0.731
MAPK8
Mitogen-activated protein kinase.
   
 0.731
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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