node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHD3 | CHD4 | ENSBTAP00000064494 | ENSBTAP00000019612 | Chromodomain helicase DNA binding protein 3. | Chromodomain helicase DNA binding protein 4. | 0.970 |
CHD3 | HDAC1 | ENSBTAP00000064494 | ENSBTAP00000070647 | Chromodomain helicase DNA binding protein 3. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | 0.990 |
CHD3 | HDAC2 | ENSBTAP00000064494 | ENSBTAP00000059606 | Chromodomain helicase DNA binding protein 3. | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | 0.986 |
CHD3 | RBBP4 | ENSBTAP00000064494 | ENSBTAP00000007758 | Chromodomain helicase DNA binding protein 3. | Histone-binding protein RBBP4; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome re [...] | 0.969 |
CHD3 | RBBP7 | ENSBTAP00000064494 | ENSBTAP00000061182 | Chromodomain helicase DNA binding protein 3. | Histone-binding protein RBBP7; Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and [...] | 0.959 |
CHD3 | SAP30 | ENSBTAP00000064494 | ENSBTAP00000020692 | Chromodomain helicase DNA binding protein 3. | Sin3A associated protein 30. | 0.623 |
CHD3 | SIN3A | ENSBTAP00000064494 | ENSBTAP00000013167 | Chromodomain helicase DNA binding protein 3. | SIN3 transcription regulator family member A. | 0.551 |
CHD4 | CHD3 | ENSBTAP00000019612 | ENSBTAP00000064494 | Chromodomain helicase DNA binding protein 4. | Chromodomain helicase DNA binding protein 3. | 0.970 |
CHD4 | DNMT1 | ENSBTAP00000019612 | ENSBTAP00000003549 | Chromodomain helicase DNA binding protein 4. | DNA (cytosine-5)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In a [...] | 0.515 |
CHD4 | HDAC1 | ENSBTAP00000019612 | ENSBTAP00000070647 | Chromodomain helicase DNA binding protein 4. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | 0.998 |
CHD4 | HDAC2 | ENSBTAP00000019612 | ENSBTAP00000059606 | Chromodomain helicase DNA binding protein 4. | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | 0.996 |
CHD4 | RBBP4 | ENSBTAP00000019612 | ENSBTAP00000007758 | Chromodomain helicase DNA binding protein 4. | Histone-binding protein RBBP4; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome re [...] | 0.979 |
CHD4 | RBBP7 | ENSBTAP00000019612 | ENSBTAP00000061182 | Chromodomain helicase DNA binding protein 4. | Histone-binding protein RBBP7; Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and [...] | 0.956 |
CHD4 | SAP30 | ENSBTAP00000019612 | ENSBTAP00000020692 | Chromodomain helicase DNA binding protein 4. | Sin3A associated protein 30. | 0.661 |
CHD4 | SIN3A | ENSBTAP00000019612 | ENSBTAP00000013167 | Chromodomain helicase DNA binding protein 4. | SIN3 transcription regulator family member A. | 0.634 |
CTBP1 | HDAC1 | ENSBTAP00000063352 | ENSBTAP00000070647 | C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | 0.983 |
CTBP1 | HDAC2 | ENSBTAP00000063352 | ENSBTAP00000059606 | C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | 0.954 |
CTBP1 | SIN3A | ENSBTAP00000063352 | ENSBTAP00000013167 | C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | SIN3 transcription regulator family member A. | 0.437 |
DNMT1 | CHD4 | ENSBTAP00000003549 | ENSBTAP00000019612 | DNA (cytosine-5)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In a [...] | Chromodomain helicase DNA binding protein 4. | 0.515 |
DNMT1 | HDAC1 | ENSBTAP00000003549 | ENSBTAP00000070647 | DNA (cytosine-5)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In a [...] | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] | 0.981 |