node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALB | KRT10 | ENSBTAP00000022763 | ENSBTAP00000017140 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (Probable). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The sh [...] | Keratin, type I cytoskeletal 10; Plays a role in the establishment of the epidermal barrier on plantar skin. | 0.538 |
DSC1 | DSG1 | ENSBTAP00000026482 | ENSBTAP00000018382 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. | Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | 0.959 |
DSC1 | KRT1 | ENSBTAP00000026482 | ENSBTAP00000055471 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. | Keratin 1; Belongs to the intermediate filament family. | 0.508 |
DSC1 | KRT10 | ENSBTAP00000026482 | ENSBTAP00000017140 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. | Keratin, type I cytoskeletal 10; Plays a role in the establishment of the epidermal barrier on plantar skin. | 0.583 |
DSC1 | LOR | ENSBTAP00000026482 | ENSBTAP00000063842 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. | Uncharacterized protein. | 0.642 |
DSC1 | PKP1 | ENSBTAP00000026482 | ENSBTAP00000055583 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. | Plakophilin-1; Seems to play a role in junctional plaques; Belongs to the beta-catenin family. | 0.847 |
DSC1 | TGM1 | ENSBTAP00000026482 | ENSBTAP00000005119 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. | Transglutaminase 1. | 0.553 |
DSG1 | DSC1 | ENSBTAP00000018382 | ENSBTAP00000026482 | Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. | 0.959 |
DSG1 | GRHL3 | ENSBTAP00000018382 | ENSBTAP00000058053 | Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Grainyhead like transcription factor 3. | 0.449 |
DSG1 | KRT1 | ENSBTAP00000018382 | ENSBTAP00000055471 | Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Keratin 1; Belongs to the intermediate filament family. | 0.783 |
DSG1 | KRT10 | ENSBTAP00000018382 | ENSBTAP00000017140 | Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Keratin, type I cytoskeletal 10; Plays a role in the establishment of the epidermal barrier on plantar skin. | 0.696 |
DSG1 | KRTDAP | ENSBTAP00000018382 | ENSBTAP00000041998 | Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Keratinocyte differentiation associated protein. | 0.499 |
DSG1 | LOR | ENSBTAP00000018382 | ENSBTAP00000063842 | Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Uncharacterized protein. | 0.663 |
DSG1 | PKP1 | ENSBTAP00000018382 | ENSBTAP00000055583 | Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Plakophilin-1; Seems to play a role in junctional plaques; Belongs to the beta-catenin family. | 0.924 |
DSG1 | TGM1 | ENSBTAP00000018382 | ENSBTAP00000005119 | Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Transglutaminase 1. | 0.678 |
DSG1 | TGM3 | ENSBTAP00000018382 | ENSBTAP00000058423 | Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain; Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 o [...] | 0.508 |
GRHL3 | DSG1 | ENSBTAP00000058053 | ENSBTAP00000018382 | Grainyhead like transcription factor 3. | Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. | 0.449 |
GRHL3 | KRT1 | ENSBTAP00000058053 | ENSBTAP00000055471 | Grainyhead like transcription factor 3. | Keratin 1; Belongs to the intermediate filament family. | 0.531 |
GRHL3 | KRT10 | ENSBTAP00000058053 | ENSBTAP00000017140 | Grainyhead like transcription factor 3. | Keratin, type I cytoskeletal 10; Plays a role in the establishment of the epidermal barrier on plantar skin. | 0.550 |
GRHL3 | LOR | ENSBTAP00000058053 | ENSBTAP00000063842 | Grainyhead like transcription factor 3. | Uncharacterized protein. | 0.487 |