node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DRD2 | GNAI3 | ENSBTAP00000014422 | ENSBTAP00000017303 | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. | Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. | 0.960 |
DRD2 | GRM2 | ENSBTAP00000014422 | ENSBTAP00000001415 | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. | Glutamate metabotropic receptor 2. | 0.525 |
DRD2 | PTGER3 | ENSBTAP00000014422 | ENSBTAP00000059944 | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. | Prostaglandin E2 receptor EP3 subtype; Receptor for prostaglandin E2 (PGE2). The various isoforms have identical ligand binding properties but interact with different second messenger systems: isoform EP3A couples to G(i)/G(o) proteins; isoform EP3B and isoform EP3C couple to G(s), and isoform EP3D couples to G(i), G(s) and G(p). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation o [...] | 0.447 |
GABBR2 | GNAI3 | ENSBTAP00000018355 | ENSBTAP00000017303 | Gamma-aminobutyric acid type B receptor subunit 2. | Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. | 0.945 |
GABBR2 | GPSM1 | ENSBTAP00000018355 | ENSBTAP00000071538 | Gamma-aminobutyric acid type B receptor subunit 2. | G protein signaling modulator 1. | 0.448 |
GABBR2 | GRM2 | ENSBTAP00000018355 | ENSBTAP00000001415 | Gamma-aminobutyric acid type B receptor subunit 2. | Glutamate metabotropic receptor 2. | 0.585 |
GNAI3 | DRD2 | ENSBTAP00000017303 | ENSBTAP00000014422 | Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. | 0.960 |
GNAI3 | GABBR2 | ENSBTAP00000017303 | ENSBTAP00000018355 | Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. | Gamma-aminobutyric acid type B receptor subunit 2. | 0.945 |
GNAI3 | GPSM1 | ENSBTAP00000017303 | ENSBTAP00000071538 | Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. | G protein signaling modulator 1. | 0.969 |
GNAI3 | GRM2 | ENSBTAP00000017303 | ENSBTAP00000001415 | Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. | Glutamate metabotropic receptor 2. | 0.948 |
GNAI3 | LPAR1 | ENSBTAP00000017303 | ENSBTAP00000059470 | Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. | Lysophosphatidic acid receptor 1; Receptor for lysophosphatidic acid (LPA). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels. Signaling triggers an increase of cytoplasmic Ca(2+) levels. Activates RALA; this leads to the activation of phospholipase C [...] | 0.966 |
GNAI3 | NRAS | ENSBTAP00000017303 | ENSBTAP00000012897 | Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. | NRAS proto-oncogene, GTPase. | 0.949 |
GNAI3 | PLCB1 | ENSBTAP00000017303 | ENSBTAP00000046644 | Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. | 0.955 |
GNAI3 | PTGER3 | ENSBTAP00000017303 | ENSBTAP00000059944 | Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. | Prostaglandin E2 receptor EP3 subtype; Receptor for prostaglandin E2 (PGE2). The various isoforms have identical ligand binding properties but interact with different second messenger systems: isoform EP3A couples to G(i)/G(o) proteins; isoform EP3B and isoform EP3C couple to G(s), and isoform EP3D couples to G(i), G(s) and G(p). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation o [...] | 0.947 |
GNAI3 | S1PR3 | ENSBTAP00000017303 | ENSBTAP00000015111 | Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. | Sphingosine-1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. | 0.953 |
GNAI3 | S1PR5 | ENSBTAP00000017303 | ENSBTAP00000004608 | Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. | Sphingosine-1-phosphate receptor 5. | 0.945 |
GPSM1 | GABBR2 | ENSBTAP00000071538 | ENSBTAP00000018355 | G protein signaling modulator 1. | Gamma-aminobutyric acid type B receptor subunit 2. | 0.448 |
GPSM1 | GNAI3 | ENSBTAP00000071538 | ENSBTAP00000017303 | G protein signaling modulator 1. | Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. | 0.969 |
GPSM1 | GRM2 | ENSBTAP00000071538 | ENSBTAP00000001415 | G protein signaling modulator 1. | Glutamate metabotropic receptor 2. | 0.465 |
GPSM1 | LPAR1 | ENSBTAP00000071538 | ENSBTAP00000059470 | G protein signaling modulator 1. | Lysophosphatidic acid receptor 1; Receptor for lysophosphatidic acid (LPA). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels. Signaling triggers an increase of cytoplasmic Ca(2+) levels. Activates RALA; this leads to the activation of phospholipase C [...] | 0.400 |