node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGAP11A | DUSP22 | ENSBTAP00000035705 | ENSBTAP00000071497 | Rho GTPase activating protein 11A. | Dual specificity phosphatase 22. | 0.412 |
ARHGAP11A | ZNF350 | ENSBTAP00000035705 | ENSBTAP00000017478 | Rho GTPase activating protein 11A. | Zinc finger protein 350; Transcriptional repressor. Binds to a specific sequence, 5'- GGGxxxCAGxxxTTT-3', within GADD45 intron 3 (By similarity). | 0.493 |
ASTN2 | LOC107131311 | ENSBTAP00000073049 | ENSBTAP00000061599 | Astrotactin 2. | Arm_2 domain-containing protein. | 0.418 |
ASTN2 | ZNF350 | ENSBTAP00000073049 | ENSBTAP00000017478 | Astrotactin 2. | Zinc finger protein 350; Transcriptional repressor. Binds to a specific sequence, 5'- GGGxxxCAGxxxTTT-3', within GADD45 intron 3 (By similarity). | 0.513 |
BRCA1 | RBBP8 | ENSBTAP00000011616 | ENSBTAP00000073495 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | DNA endonuclease RBBP8; Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse. Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phas [...] | 0.999 |
BRCA1 | ZNF350 | ENSBTAP00000011616 | ENSBTAP00000017478 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Zinc finger protein 350; Transcriptional repressor. Binds to a specific sequence, 5'- GGGxxxCAGxxxTTT-3', within GADD45 intron 3 (By similarity). | 0.642 |
COPS5 | PPP2CB | ENSBTAP00000003609 | ENSBTAP00000012182 | COP9 signalosome subunit 5. | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform; PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. | 0.467 |
COPS5 | ZNF350 | ENSBTAP00000003609 | ENSBTAP00000017478 | COP9 signalosome subunit 5. | Zinc finger protein 350; Transcriptional repressor. Binds to a specific sequence, 5'- GGGxxxCAGxxxTTT-3', within GADD45 intron 3 (By similarity). | 0.614 |
DUSP22 | ARHGAP11A | ENSBTAP00000071497 | ENSBTAP00000035705 | Dual specificity phosphatase 22. | Rho GTPase activating protein 11A. | 0.412 |
DUSP22 | ZNF350 | ENSBTAP00000071497 | ENSBTAP00000017478 | Dual specificity phosphatase 22. | Zinc finger protein 350; Transcriptional repressor. Binds to a specific sequence, 5'- GGGxxxCAGxxxTTT-3', within GADD45 intron 3 (By similarity). | 0.466 |
GFRA4 | ZNF350 | ENSBTAP00000055024 | ENSBTAP00000017478 | GDNF family receptor alpha 4. | Zinc finger protein 350; Transcriptional repressor. Binds to a specific sequence, 5'- GGGxxxCAGxxxTTT-3', within GADD45 intron 3 (By similarity). | 0.569 |
LOC107131311 | ASTN2 | ENSBTAP00000061599 | ENSBTAP00000073049 | Arm_2 domain-containing protein. | Astrotactin 2. | 0.418 |
LOC107131311 | ZNF350 | ENSBTAP00000061599 | ENSBTAP00000017478 | Arm_2 domain-containing protein. | Zinc finger protein 350; Transcriptional repressor. Binds to a specific sequence, 5'- GGGxxxCAGxxxTTT-3', within GADD45 intron 3 (By similarity). | 0.760 |
PPP2CB | COPS5 | ENSBTAP00000012182 | ENSBTAP00000003609 | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform; PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. | COP9 signalosome subunit 5. | 0.467 |
PPP2CB | ZNF350 | ENSBTAP00000012182 | ENSBTAP00000017478 | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform; PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. | Zinc finger protein 350; Transcriptional repressor. Binds to a specific sequence, 5'- GGGxxxCAGxxxTTT-3', within GADD45 intron 3 (By similarity). | 0.410 |
RBBP8 | BRCA1 | ENSBTAP00000073495 | ENSBTAP00000011616 | DNA endonuclease RBBP8; Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse. Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phas [...] | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.999 |
RBBP8 | ZNF350 | ENSBTAP00000073495 | ENSBTAP00000017478 | DNA endonuclease RBBP8; Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse. Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phas [...] | Zinc finger protein 350; Transcriptional repressor. Binds to a specific sequence, 5'- GGGxxxCAGxxxTTT-3', within GADD45 intron 3 (By similarity). | 0.640 |
TRPC4AP | ZNF350 | ENSBTAP00000064859 | ENSBTAP00000017478 | Transient receptor potential cation channel subfamily C member 4 associated protein. | Zinc finger protein 350; Transcriptional repressor. Binds to a specific sequence, 5'- GGGxxxCAGxxxTTT-3', within GADD45 intron 3 (By similarity). | 0.538 |
ZNF350 | ARHGAP11A | ENSBTAP00000017478 | ENSBTAP00000035705 | Zinc finger protein 350; Transcriptional repressor. Binds to a specific sequence, 5'- GGGxxxCAGxxxTTT-3', within GADD45 intron 3 (By similarity). | Rho GTPase activating protein 11A. | 0.493 |
ZNF350 | ASTN2 | ENSBTAP00000017478 | ENSBTAP00000073049 | Zinc finger protein 350; Transcriptional repressor. Binds to a specific sequence, 5'- GGGxxxCAGxxxTTT-3', within GADD45 intron 3 (By similarity). | Astrotactin 2. | 0.513 |