node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BUB1 | FZR1 | ENSBTAP00000028226 | ENSBTAP00000058619 | BUB1 mitotic checkpoint serine/threonine kinase. | Fizzy/cell division cycle 20 related 1 (Drosophila). | 0.747 |
BUB1 | MAD1L1 | ENSBTAP00000028226 | ENSBTAP00000060075 | BUB1 mitotic checkpoint serine/threonine kinase. | Mitotic arrest deficient 1 like 1. | 0.994 |
BUB1 | MAD2L2 | ENSBTAP00000028226 | ENSBTAP00000061520 | BUB1 mitotic checkpoint serine/threonine kinase. | Mitotic spindle assembly checkpoint protein MAD2B; Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks [...] | 0.930 |
BUB1 | POLE | ENSBTAP00000028226 | ENSBTAP00000009882 | BUB1 mitotic checkpoint serine/threonine kinase. | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | 0.639 |
FZR1 | BUB1 | ENSBTAP00000058619 | ENSBTAP00000028226 | Fizzy/cell division cycle 20 related 1 (Drosophila). | BUB1 mitotic checkpoint serine/threonine kinase. | 0.747 |
FZR1 | MAD1L1 | ENSBTAP00000058619 | ENSBTAP00000060075 | Fizzy/cell division cycle 20 related 1 (Drosophila). | Mitotic arrest deficient 1 like 1. | 0.970 |
FZR1 | MAD2L2 | ENSBTAP00000058619 | ENSBTAP00000061520 | Fizzy/cell division cycle 20 related 1 (Drosophila). | Mitotic spindle assembly checkpoint protein MAD2B; Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks [...] | 0.936 |
MAD1L1 | BUB1 | ENSBTAP00000060075 | ENSBTAP00000028226 | Mitotic arrest deficient 1 like 1. | BUB1 mitotic checkpoint serine/threonine kinase. | 0.994 |
MAD1L1 | FZR1 | ENSBTAP00000060075 | ENSBTAP00000058619 | Mitotic arrest deficient 1 like 1. | Fizzy/cell division cycle 20 related 1 (Drosophila). | 0.970 |
MAD1L1 | MAD2L2 | ENSBTAP00000060075 | ENSBTAP00000061520 | Mitotic arrest deficient 1 like 1. | Mitotic spindle assembly checkpoint protein MAD2B; Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks [...] | 0.939 |
MAD2L2 | BUB1 | ENSBTAP00000061520 | ENSBTAP00000028226 | Mitotic spindle assembly checkpoint protein MAD2B; Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks [...] | BUB1 mitotic checkpoint serine/threonine kinase. | 0.930 |
MAD2L2 | FZR1 | ENSBTAP00000061520 | ENSBTAP00000058619 | Mitotic spindle assembly checkpoint protein MAD2B; Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks [...] | Fizzy/cell division cycle 20 related 1 (Drosophila). | 0.936 |
MAD2L2 | MAD1L1 | ENSBTAP00000061520 | ENSBTAP00000060075 | Mitotic spindle assembly checkpoint protein MAD2B; Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks [...] | Mitotic arrest deficient 1 like 1. | 0.939 |
MAD2L2 | POLD1 | ENSBTAP00000061520 | ENSBTAP00000014714 | Mitotic spindle assembly checkpoint protein MAD2B; Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks [...] | DNA polymerase delta catalytic subunit; As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol- delta4), displays differences in catalytic activity. Most notably, expresses higher pro [...] | 0.945 |
MAD2L2 | POLD2 | ENSBTAP00000061520 | ENSBTAP00000072531 | Mitotic spindle assembly checkpoint protein MAD2B; Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks [...] | DNA polymerase delta subunit 2; Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex. As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Pol-delta3 and Pol- delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4. Although both Pol- delta3 and [...] | 0.975 |
MAD2L2 | POLE | ENSBTAP00000061520 | ENSBTAP00000009882 | Mitotic spindle assembly checkpoint protein MAD2B; Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks [...] | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. | 0.894 |
MAD2L2 | REV1 | ENSBTAP00000061520 | ENSBTAP00000073575 | Mitotic spindle assembly checkpoint protein MAD2B; Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks [...] | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. | 0.977 |
MAD2L2 | REV3L | ENSBTAP00000061520 | ENSBTAP00000053310 | Mitotic spindle assembly checkpoint protein MAD2B; Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks [...] | REV3 like, DNA directed polymerase zeta catalytic subunit. | 0.996 |
MAD2L2 | SHLD2 | ENSBTAP00000061520 | ENSBTAP00000025542 | Mitotic spindle assembly checkpoint protein MAD2B; Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks [...] | Shieldin complex subunit 2. | 0.947 |
MAD2L2 | SHLD3 | ENSBTAP00000061520 | ENSBTAP00000048806 | Mitotic spindle assembly checkpoint protein MAD2B; Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks [...] | Shieldin complex subunit 3. | 0.953 |