node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACSBG1 | ACSL1 | ENSBTAP00000058590 | ENSBTAP00000061904 | Long-chain-fatty-acid--CoA ligase ACSBG1; Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids. | Acyl-CoA synthetase long chain family member 1. | 0.723 |
ACSBG1 | ACSL5 | ENSBTAP00000058590 | ENSBTAP00000053897 | Long-chain-fatty-acid--CoA ligase ACSBG1; Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids. | Acyl-CoA synthetase long-chain family member 5. | 0.712 |
ACSBG1 | MECR | ENSBTAP00000058590 | ENSBTAP00000022932 | Long-chain-fatty-acid--CoA ligase ACSBG1; Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids. | Enoyl-[acyl-carrier-protein] reductase, mitochondrial; Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Has a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). Belongs to the zinc-containing alcohol dehydrogenase family. Quin [...] | 0.420 |
ACSBG1 | PPT1 | ENSBTAP00000058590 | ENSBTAP00000017780 | Long-chain-fatty-acid--CoA ligase ACSBG1; Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids. | Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons. | 0.842 |
ACSBG1 | PPT2 | ENSBTAP00000058590 | ENSBTAP00000062999 | Long-chain-fatty-acid--CoA ligase ACSBG1; Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids. | Lysosomal thioesterase PPT2; Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins (By similarity). | 0.823 |
ACSL1 | ACSBG1 | ENSBTAP00000061904 | ENSBTAP00000058590 | Acyl-CoA synthetase long chain family member 1. | Long-chain-fatty-acid--CoA ligase ACSBG1; Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids. | 0.723 |
ACSL1 | ACSL5 | ENSBTAP00000061904 | ENSBTAP00000053897 | Acyl-CoA synthetase long chain family member 1. | Acyl-CoA synthetase long-chain family member 5. | 0.658 |
ACSL1 | PPT1 | ENSBTAP00000061904 | ENSBTAP00000017780 | Acyl-CoA synthetase long chain family member 1. | Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons. | 0.849 |
ACSL1 | PPT2 | ENSBTAP00000061904 | ENSBTAP00000062999 | Acyl-CoA synthetase long chain family member 1. | Lysosomal thioesterase PPT2; Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins (By similarity). | 0.841 |
ACSL5 | ACSBG1 | ENSBTAP00000053897 | ENSBTAP00000058590 | Acyl-CoA synthetase long-chain family member 5. | Long-chain-fatty-acid--CoA ligase ACSBG1; Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids. | 0.712 |
ACSL5 | ACSL1 | ENSBTAP00000053897 | ENSBTAP00000061904 | Acyl-CoA synthetase long-chain family member 5. | Acyl-CoA synthetase long chain family member 1. | 0.658 |
ACSL5 | PPT1 | ENSBTAP00000053897 | ENSBTAP00000017780 | Acyl-CoA synthetase long-chain family member 5. | Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons. | 0.846 |
ACSL5 | PPT2 | ENSBTAP00000053897 | ENSBTAP00000062999 | Acyl-CoA synthetase long-chain family member 5. | Lysosomal thioesterase PPT2; Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins (By similarity). | 0.843 |
CLN3 | CLN5 | ENSBTAP00000023952 | ENSBTAP00000025093 | Battenin. | Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Belongs to the CLN5 family. | 0.921 |
CLN3 | CLN6 | ENSBTAP00000023952 | ENSBTAP00000007315 | Battenin. | CLN6 transmembrane ER protein. | 0.923 |
CLN3 | CLN8 | ENSBTAP00000023952 | ENSBTAP00000068985 | Battenin. | TLC domain-containing protein. | 0.874 |
CLN3 | PPT1 | ENSBTAP00000023952 | ENSBTAP00000017780 | Battenin. | Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons. | 0.910 |
CLN3 | TPP1 | ENSBTAP00000023952 | ENSBTAP00000062713 | Battenin. | Tripeptidyl-peptidase 1; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity). | 0.836 |
CLN5 | CLN3 | ENSBTAP00000025093 | ENSBTAP00000023952 | Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Belongs to the CLN5 family. | Battenin. | 0.921 |
CLN5 | CLN6 | ENSBTAP00000025093 | ENSBTAP00000007315 | Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Belongs to the CLN5 family. | CLN6 transmembrane ER protein. | 0.946 |