node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCB11 | CYP7A1 | ENSBTAP00000043977 | ENSBTAP00000006957 | ATP binding cassette subfamily B member 11. | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | 0.820 |
ABCB11 | CYP8B1 | ENSBTAP00000043977 | ENSBTAP00000045414 | ATP binding cassette subfamily B member 11. | Cytochrome P450, family 8, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | 0.787 |
ABCB11 | GPBAR1 | ENSBTAP00000043977 | ENSBTAP00000005120 | ATP binding cassette subfamily B member 11. | G-protein coupled bile acid receptor 1; Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. Involved in bile acid promoted GLP1R secretion (By similarity). | 0.574 |
ABCB11 | NR0B2 | ENSBTAP00000043977 | ENSBTAP00000019772 | ATP binding cassette subfamily B member 11. | Nuclear receptor subfamily 0 group B member 2. | 0.759 |
ABCB11 | NR1H4 | ENSBTAP00000043977 | ENSBTAP00000018079 | ATP binding cassette subfamily B member 11. | Bile acid receptor; Ligand-activated transcription factor. Receptor for bile acids (BAs) such as chenodeoxycholic acid (CDCA), lithocholic acid, deoxycholic acid (DCA) and allocholic acid (ACA). Plays a essential role in BA homeostasis through the regulation of genes involved in BA synthesis, conjugation and enterohepatic circulation. Also regulates lipid and glucose homeostasis and is involved innate immune response. The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' in wh [...] | 0.849 |
CYP7A1 | ABCB11 | ENSBTAP00000006957 | ENSBTAP00000043977 | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | ATP binding cassette subfamily B member 11. | 0.820 |
CYP7A1 | GPBAR1 | ENSBTAP00000006957 | ENSBTAP00000005120 | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | G-protein coupled bile acid receptor 1; Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. Involved in bile acid promoted GLP1R secretion (By similarity). | 0.667 |
CYP7A1 | NR0B2 | ENSBTAP00000006957 | ENSBTAP00000019772 | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | Nuclear receptor subfamily 0 group B member 2. | 0.774 |
CYP7A1 | NR1H4 | ENSBTAP00000006957 | ENSBTAP00000018079 | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | Bile acid receptor; Ligand-activated transcription factor. Receptor for bile acids (BAs) such as chenodeoxycholic acid (CDCA), lithocholic acid, deoxycholic acid (DCA) and allocholic acid (ACA). Plays a essential role in BA homeostasis through the regulation of genes involved in BA synthesis, conjugation and enterohepatic circulation. Also regulates lipid and glucose homeostasis and is involved innate immune response. The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' in wh [...] | 0.900 |
CYP7A1 | PPARGC1A | ENSBTAP00000006957 | ENSBTAP00000022636 | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] | 0.493 |
CYP8B1 | ABCB11 | ENSBTAP00000045414 | ENSBTAP00000043977 | Cytochrome P450, family 8, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | ATP binding cassette subfamily B member 11. | 0.787 |
CYP8B1 | GPBAR1 | ENSBTAP00000045414 | ENSBTAP00000005120 | Cytochrome P450, family 8, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | G-protein coupled bile acid receptor 1; Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. Involved in bile acid promoted GLP1R secretion (By similarity). | 0.667 |
CYP8B1 | NR0B2 | ENSBTAP00000045414 | ENSBTAP00000019772 | Cytochrome P450, family 8, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | Nuclear receptor subfamily 0 group B member 2. | 0.695 |
CYP8B1 | NR1H4 | ENSBTAP00000045414 | ENSBTAP00000018079 | Cytochrome P450, family 8, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | Bile acid receptor; Ligand-activated transcription factor. Receptor for bile acids (BAs) such as chenodeoxycholic acid (CDCA), lithocholic acid, deoxycholic acid (DCA) and allocholic acid (ACA). Plays a essential role in BA homeostasis through the regulation of genes involved in BA synthesis, conjugation and enterohepatic circulation. Also regulates lipid and glucose homeostasis and is involved innate immune response. The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' in wh [...] | 0.845 |
GPBAR1 | ABCB11 | ENSBTAP00000005120 | ENSBTAP00000043977 | G-protein coupled bile acid receptor 1; Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. Involved in bile acid promoted GLP1R secretion (By similarity). | ATP binding cassette subfamily B member 11. | 0.574 |
GPBAR1 | CYP7A1 | ENSBTAP00000005120 | ENSBTAP00000006957 | G-protein coupled bile acid receptor 1; Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. Involved in bile acid promoted GLP1R secretion (By similarity). | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | 0.667 |
GPBAR1 | CYP8B1 | ENSBTAP00000005120 | ENSBTAP00000045414 | G-protein coupled bile acid receptor 1; Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. Involved in bile acid promoted GLP1R secretion (By similarity). | Cytochrome P450, family 8, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | 0.667 |
GPBAR1 | NR1H4 | ENSBTAP00000005120 | ENSBTAP00000018079 | G-protein coupled bile acid receptor 1; Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. Involved in bile acid promoted GLP1R secretion (By similarity). | Bile acid receptor; Ligand-activated transcription factor. Receptor for bile acids (BAs) such as chenodeoxycholic acid (CDCA), lithocholic acid, deoxycholic acid (DCA) and allocholic acid (ACA). Plays a essential role in BA homeostasis through the regulation of genes involved in BA synthesis, conjugation and enterohepatic circulation. Also regulates lipid and glucose homeostasis and is involved innate immune response. The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' in wh [...] | 0.955 |
GPBAR1 | PPARGC1A | ENSBTAP00000005120 | ENSBTAP00000022636 | G-protein coupled bile acid receptor 1; Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. Involved in bile acid promoted GLP1R secretion (By similarity). | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] | 0.407 |
NCOA1 | NCOA2 | ENSBTAP00000055281 | ENSBTAP00000067457 | Nuclear receptor coactivator. | Nuclear receptor coactivator. | 0.994 |