node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GCLC | GCLM | ENSBTAP00000070904 | ENSBTAP00000026855 | Glutamate-cysteine ligase catalytic subunit. | Glutamate--cysteine ligase regulatory subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | 0.999 |
GCLC | KEAP1 | ENSBTAP00000070904 | ENSBTAP00000004604 | Glutamate-cysteine ligase catalytic subunit. | Kelch like ECH associated protein 1. | 0.900 |
GCLC | MAF | ENSBTAP00000070904 | ENSBTAP00000053555 | Glutamate-cysteine ligase catalytic subunit. | Transcription factor Maf; Acts as a transcriptional activator or repressor. When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T-helper 2 (Th2) cell [...] | 0.588 |
GCLC | MAFF | ENSBTAP00000070904 | ENSBTAP00000028574 | Glutamate-cysteine ligase catalytic subunit. | Transcription factor MafF; Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition. | 0.445 |
GCLC | MAFG | ENSBTAP00000070904 | ENSBTAP00000000044 | Glutamate-cysteine ligase catalytic subunit. | Transcription factor MafG; Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NFE2L2. Activates globin g [...] | 0.598 |
GCLC | MAFK | ENSBTAP00000070904 | ENSBTAP00000025702 | Glutamate-cysteine ligase catalytic subunit. | MAF bZIP transcription factor K. | 0.495 |
GCLC | NFE2L1 | ENSBTAP00000070904 | ENSBTAP00000060634 | Glutamate-cysteine ligase catalytic subunit. | Endoplasmic reticulum membrane sensor NFE2L1; [Endoplasmic reticulum membrane sensor NFE2L1]: Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor (By similarity). Constitutes a precursor of the transcription factor NRF1 (By similarity). Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition (By similarity). In response to stress, it is released from the endoplasmic reticulum membrane following cleavage by the protease DDI2 and translocates into [...] | 0.572 |
GCLM | GCLC | ENSBTAP00000026855 | ENSBTAP00000070904 | Glutamate--cysteine ligase regulatory subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | Glutamate-cysteine ligase catalytic subunit. | 0.999 |
GCLM | KEAP1 | ENSBTAP00000026855 | ENSBTAP00000004604 | Glutamate--cysteine ligase regulatory subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | Kelch like ECH associated protein 1. | 0.889 |
GCLM | MAF | ENSBTAP00000026855 | ENSBTAP00000053555 | Glutamate--cysteine ligase regulatory subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | Transcription factor Maf; Acts as a transcriptional activator or repressor. When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T-helper 2 (Th2) cell [...] | 0.565 |
GCLM | MAFG | ENSBTAP00000026855 | ENSBTAP00000000044 | Glutamate--cysteine ligase regulatory subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | Transcription factor MafG; Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NFE2L2. Activates globin g [...] | 0.548 |
GCLM | NFE2L1 | ENSBTAP00000026855 | ENSBTAP00000060634 | Glutamate--cysteine ligase regulatory subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | Endoplasmic reticulum membrane sensor NFE2L1; [Endoplasmic reticulum membrane sensor NFE2L1]: Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor (By similarity). Constitutes a precursor of the transcription factor NRF1 (By similarity). Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition (By similarity). In response to stress, it is released from the endoplasmic reticulum membrane following cleavage by the protease DDI2 and translocates into [...] | 0.564 |
KEAP1 | GCLC | ENSBTAP00000004604 | ENSBTAP00000070904 | Kelch like ECH associated protein 1. | Glutamate-cysteine ligase catalytic subunit. | 0.900 |
KEAP1 | GCLM | ENSBTAP00000004604 | ENSBTAP00000026855 | Kelch like ECH associated protein 1. | Glutamate--cysteine ligase regulatory subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | 0.889 |
KEAP1 | MAF | ENSBTAP00000004604 | ENSBTAP00000053555 | Kelch like ECH associated protein 1. | Transcription factor Maf; Acts as a transcriptional activator or repressor. When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T-helper 2 (Th2) cell [...] | 0.793 |
KEAP1 | MAFF | ENSBTAP00000004604 | ENSBTAP00000028574 | Kelch like ECH associated protein 1. | Transcription factor MafF; Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition. | 0.646 |
KEAP1 | MAFG | ENSBTAP00000004604 | ENSBTAP00000000044 | Kelch like ECH associated protein 1. | Transcription factor MafG; Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NFE2L2. Activates globin g [...] | 0.655 |
KEAP1 | MAFK | ENSBTAP00000004604 | ENSBTAP00000025702 | Kelch like ECH associated protein 1. | MAF bZIP transcription factor K. | 0.682 |
KEAP1 | NFE2L1 | ENSBTAP00000004604 | ENSBTAP00000060634 | Kelch like ECH associated protein 1. | Endoplasmic reticulum membrane sensor NFE2L1; [Endoplasmic reticulum membrane sensor NFE2L1]: Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor (By similarity). Constitutes a precursor of the transcription factor NRF1 (By similarity). Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition (By similarity). In response to stress, it is released from the endoplasmic reticulum membrane following cleavage by the protease DDI2 and translocates into [...] | 0.765 |
MAF | GCLC | ENSBTAP00000053555 | ENSBTAP00000070904 | Transcription factor Maf; Acts as a transcriptional activator or repressor. When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T-helper 2 (Th2) cell [...] | Glutamate-cysteine ligase catalytic subunit. | 0.588 |