TBX21 protein (Bos taurus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Current Organism:

Bos taurus

NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD4	FOXP3	ENSBTAP00000037566	ENSBTAP00000064761	CD4 molecule.	Forkhead box P3.	0.957
CD4	GATA3	ENSBTAP00000037566	ENSBTAP00000068033	CD4 molecule.	Trans-acting T-cell-specific transcription factor GATA-3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses (By similarity).	0.841
CD4	IFNG	ENSBTAP00000037566	ENSBTAP00000016634	CD4 molecule.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.965
CD4	IL17A	ENSBTAP00000037566	ENSBTAP00000002786	CD4 molecule.	Interleukin-17A; Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines.	0.950
CD4	IL4	ENSBTAP00000037566	ENSBTAP00000021215	CD4 molecule.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.949
CD4	RORC	ENSBTAP00000037566	ENSBTAP00000070415	CD4 molecule.	RAR related orphan receptor C.	0.743
CD4	RUNX1	ENSBTAP00000037566	ENSBTAP00000006224	CD4 molecule.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.534
CD4	RUNX3	ENSBTAP00000037566	ENSBTAP00000061160	CD4 molecule.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.629
CD4	TBX21	ENSBTAP00000037566	ENSBTAP00000018875	CD4 molecule.	T-box transcription factor 21.	0.850
FOXP3	CD4	ENSBTAP00000064761	ENSBTAP00000037566	Forkhead box P3.	CD4 molecule.	0.957
FOXP3	GATA2	ENSBTAP00000064761	ENSBTAP00000066251	Forkhead box P3.	GATA binding protein 2.	0.545
FOXP3	GATA3	ENSBTAP00000064761	ENSBTAP00000068033	Forkhead box P3.	Trans-acting T-cell-specific transcription factor GATA-3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses (By similarity).	0.950
FOXP3	IFNG	ENSBTAP00000064761	ENSBTAP00000016634	Forkhead box P3.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.936
FOXP3	IL17A	ENSBTAP00000064761	ENSBTAP00000002786	Forkhead box P3.	Interleukin-17A; Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines.	0.920
FOXP3	IL4	ENSBTAP00000064761	ENSBTAP00000021215	Forkhead box P3.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.903
FOXP3	RORC	ENSBTAP00000064761	ENSBTAP00000070415	Forkhead box P3.	RAR related orphan receptor C.	0.983
FOXP3	RUNX1	ENSBTAP00000064761	ENSBTAP00000006224	Forkhead box P3.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.984
FOXP3	RUNX3	ENSBTAP00000064761	ENSBTAP00000061160	Forkhead box P3.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.881
FOXP3	TBX21	ENSBTAP00000064761	ENSBTAP00000018875	Forkhead box P3.	T-box transcription factor 21.	0.844
GATA2	FOXP3	ENSBTAP00000066251	ENSBTAP00000064761	GATA binding protein 2.	Forkhead box P3.	0.545

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