node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCA1 | ABCG1 | ENSBTAP00000027538 | ENSBTAP00000066586 | ATP binding cassette subfamily A member 1. | ATP binding cassette subfamily G member 1. | 0.536 |
ABCA1 | APOA1 | ENSBTAP00000027538 | ENSBTAP00000002914 | ATP binding cassette subfamily A member 1. | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. | 0.999 |
ABCA1 | APOB | ENSBTAP00000027538 | ENSBTAP00000038799 | ATP binding cassette subfamily A member 1. | Apolipoprotein B. | 0.770 |
ABCA1 | APOE | ENSBTAP00000027538 | ENSBTAP00000013354 | ATP binding cassette subfamily A member 1. | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | 0.923 |
ABCA1 | NPC1L1 | ENSBTAP00000027538 | ENSBTAP00000053360 | ATP binding cassette subfamily A member 1. | NPC1 like intracellular cholesterol transporter 1. | 0.715 |
ABCA1 | SCARB1 | ENSBTAP00000027538 | ENSBTAP00000018959 | ATP binding cassette subfamily A member 1. | Scavenger receptor class B member 1; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB- containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Belongs to the CD36 family. | 0.893 |
ABCG1 | ABCA1 | ENSBTAP00000066586 | ENSBTAP00000027538 | ATP binding cassette subfamily G member 1. | ATP binding cassette subfamily A member 1. | 0.536 |
ABCG1 | APOA1 | ENSBTAP00000066586 | ENSBTAP00000002914 | ATP binding cassette subfamily G member 1. | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. | 0.932 |
ABCG1 | APOB | ENSBTAP00000066586 | ENSBTAP00000038799 | ATP binding cassette subfamily G member 1. | Apolipoprotein B. | 0.677 |
ABCG1 | APOE | ENSBTAP00000066586 | ENSBTAP00000013354 | ATP binding cassette subfamily G member 1. | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | 0.852 |
ABCG1 | NPC1L1 | ENSBTAP00000066586 | ENSBTAP00000053360 | ATP binding cassette subfamily G member 1. | NPC1 like intracellular cholesterol transporter 1. | 0.637 |
ABCG1 | SCARB1 | ENSBTAP00000066586 | ENSBTAP00000018959 | ATP binding cassette subfamily G member 1. | Scavenger receptor class B member 1; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB- containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Belongs to the CD36 family. | 0.883 |
ABCG1 | STAR | ENSBTAP00000066586 | ENSBTAP00000044633 | ATP binding cassette subfamily G member 1. | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity). | 0.412 |
APOA1 | ABCA1 | ENSBTAP00000002914 | ENSBTAP00000027538 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. | ATP binding cassette subfamily A member 1. | 0.999 |
APOA1 | ABCG1 | ENSBTAP00000002914 | ENSBTAP00000066586 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. | ATP binding cassette subfamily G member 1. | 0.932 |
APOA1 | APOB | ENSBTAP00000002914 | ENSBTAP00000038799 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. | Apolipoprotein B. | 0.997 |
APOA1 | APOE | ENSBTAP00000002914 | ENSBTAP00000013354 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] | 0.998 |
APOA1 | CD81 | ENSBTAP00000002914 | ENSBTAP00000054606 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. | CD81 antigen; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells. Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production. In T cells, facilitates the localization of CD247/ [...] | 0.440 |
APOA1 | NPC1L1 | ENSBTAP00000002914 | ENSBTAP00000053360 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. | NPC1 like intracellular cholesterol transporter 1. | 0.592 |
APOA1 | SCARB1 | ENSBTAP00000002914 | ENSBTAP00000018959 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. | Scavenger receptor class B member 1; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB- containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Belongs to the CD36 family. | 0.998 |