| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FBLIM1 | FERMT1 | ENSBTAP00000056771 | ENSBTAP00000066609 | Filamin-binding LIM protein 1; Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion (By similarity). | Fermitin family member 1. | 0.780 |
| FBLIM1 | FERMT2 | ENSBTAP00000056771 | ENSBTAP00000019278 | Filamin-binding LIM protein 1; Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion (By similarity). | Fermitin family member 2. | 0.989 |
| FBLIM1 | FERMT3 | ENSBTAP00000056771 | ENSBTAP00000055364 | Filamin-binding LIM protein 1; Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion (By similarity). | Fermitin family homolog 3; Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs). Belongs to the kindlin family. | 0.665 |
| FERMT1 | FBLIM1 | ENSBTAP00000066609 | ENSBTAP00000056771 | Fermitin family member 1. | Filamin-binding LIM protein 1; Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion (By similarity). | 0.780 |
| FERMT1 | FERMT2 | ENSBTAP00000066609 | ENSBTAP00000019278 | Fermitin family member 1. | Fermitin family member 2. | 0.815 |
| FERMT1 | FERMT3 | ENSBTAP00000066609 | ENSBTAP00000055364 | Fermitin family member 1. | Fermitin family homolog 3; Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs). Belongs to the kindlin family. | 0.865 |
| FERMT1 | ILK | ENSBTAP00000066609 | ENSBTAP00000000927 | Fermitin family member 1. | Integrin-linked protein kinase; Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. | 0.904 |
| FERMT1 | ITGB1 | ENSBTAP00000066609 | ENSBTAP00000052015 | Fermitin family member 1. | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.576 |
| FERMT1 | ITGB3 | ENSBTAP00000066609 | ENSBTAP00000013173 | Fermitin family member 1. | Integrin beta; Belongs to the integrin beta chain family. | 0.758 |
| FERMT1 | ITGB8 | ENSBTAP00000066609 | ENSBTAP00000004833 | Fermitin family member 1. | Integrin beta; Belongs to the integrin beta chain family. | 0.797 |
| FERMT1 | PARVA | ENSBTAP00000066609 | ENSBTAP00000061139 | Fermitin family member 1. | Parvin alpha. | 0.705 |
| FERMT1 | PARVB | ENSBTAP00000066609 | ENSBTAP00000066260 | Fermitin family member 1. | Parvin beta. | 0.712 |
| FERMT1 | VCL | ENSBTAP00000066609 | ENSBTAP00000053644 | Fermitin family member 1. | Vinculin. | 0.769 |
| FERMT2 | FBLIM1 | ENSBTAP00000019278 | ENSBTAP00000056771 | Fermitin family member 2. | Filamin-binding LIM protein 1; Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion (By similarity). | 0.989 |
| FERMT2 | FERMT1 | ENSBTAP00000019278 | ENSBTAP00000066609 | Fermitin family member 2. | Fermitin family member 1. | 0.815 |
| FERMT2 | FERMT3 | ENSBTAP00000019278 | ENSBTAP00000055364 | Fermitin family member 2. | Fermitin family homolog 3; Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs). Belongs to the kindlin family. | 0.835 |
| FERMT2 | ILK | ENSBTAP00000019278 | ENSBTAP00000000927 | Fermitin family member 2. | Integrin-linked protein kinase; Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. | 0.949 |
| FERMT2 | ITGB1 | ENSBTAP00000019278 | ENSBTAP00000052015 | Fermitin family member 2. | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.860 |
| FERMT2 | ITGB3 | ENSBTAP00000019278 | ENSBTAP00000013173 | Fermitin family member 2. | Integrin beta; Belongs to the integrin beta chain family. | 0.843 |
| FERMT2 | ITGB8 | ENSBTAP00000019278 | ENSBTAP00000004833 | Fermitin family member 2. | Integrin beta; Belongs to the integrin beta chain family. | 0.803 |
