node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EGFR | HGF | ENSBTAP00000070620 | ENSBTAP00000023490 | Receptor protein-tyrosine kinase. | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily. | 0.946 |
EGFR | IGF1 | ENSBTAP00000070620 | ENSBTAP00000055243 | Receptor protein-tyrosine kinase. | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] | 0.975 |
EGFR | PDGFA | ENSBTAP00000070620 | ENSBTAP00000063379 | Receptor protein-tyrosine kinase. | Platelet-derived growth factor subunit A; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by t [...] | 0.949 |
EGFR | PDGFB | ENSBTAP00000070620 | ENSBTAP00000056346 | Receptor protein-tyrosine kinase. | Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. | 0.948 |
EGFR | PDGFC | ENSBTAP00000070620 | ENSBTAP00000053852 | Receptor protein-tyrosine kinase. | Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.951 |
EGFR | PDGFD | ENSBTAP00000070620 | ENSBTAP00000046207 | Receptor protein-tyrosine kinase. | Platelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. | 0.922 |
EGFR | PDGFRA | ENSBTAP00000070620 | ENSBTAP00000068814 | Receptor protein-tyrosine kinase. | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. | 0.967 |
EGFR | PDGFRB | ENSBTAP00000070620 | ENSBTAP00000064374 | Receptor protein-tyrosine kinase. | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. | 0.977 |
EGFR | VEGFC | ENSBTAP00000070620 | ENSBTAP00000019613 | Receptor protein-tyrosine kinase. | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.794 |
EGFR | VEGFD | ENSBTAP00000070620 | ENSBTAP00000012474 | Receptor protein-tyrosine kinase. | Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. | 0.742 |
HGF | EGFR | ENSBTAP00000023490 | ENSBTAP00000070620 | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily. | Receptor protein-tyrosine kinase. | 0.946 |
HGF | IGF1 | ENSBTAP00000023490 | ENSBTAP00000055243 | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily. | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] | 0.982 |
HGF | PDGFA | ENSBTAP00000023490 | ENSBTAP00000063379 | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily. | Platelet-derived growth factor subunit A; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by t [...] | 0.936 |
HGF | PDGFB | ENSBTAP00000023490 | ENSBTAP00000056346 | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily. | Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. | 0.941 |
HGF | PDGFC | ENSBTAP00000023490 | ENSBTAP00000053852 | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily. | Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.924 |
HGF | PDGFD | ENSBTAP00000023490 | ENSBTAP00000046207 | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily. | Platelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. | 0.927 |
HGF | PDGFRA | ENSBTAP00000023490 | ENSBTAP00000068814 | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily. | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. | 0.805 |
HGF | PDGFRB | ENSBTAP00000023490 | ENSBTAP00000064374 | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily. | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. | 0.825 |
HGF | VEGFC | ENSBTAP00000023490 | ENSBTAP00000019613 | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily. | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. | 0.959 |
HGF | VEGFD | ENSBTAP00000023490 | ENSBTAP00000012474 | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily. | Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. | 0.953 |