node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENPP3 | GUCY1A1 | ENSBTAP00000026900 | ENSBTAP00000064987 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (By similarity). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic [...] | Guanylate cyclase soluble subunit alpha-1. | 0.902 |
ENPP3 | GUCY1B1 | ENSBTAP00000026900 | ENSBTAP00000005009 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (By similarity). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic [...] | Guanylate cyclase soluble subunit beta-1; Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | 0.907 |
ENPP3 | ITPA | ENSBTAP00000026900 | ENSBTAP00000072806 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (By similarity). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic [...] | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.925 |
ENPP3 | LOC112449027 | ENSBTAP00000026900 | ENSBTAP00000009810 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (By similarity). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic [...] | Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | 0.907 |
ENPP3 | NUDT2 | ENSBTAP00000026900 | ENSBTAP00000042493 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (By similarity). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic [...] | Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis. | 0.932 |
ENPP3 | PKLR | ENSBTAP00000026900 | ENSBTAP00000061000 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (By similarity). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic [...] | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.901 |
ENPP3 | PKM | ENSBTAP00000026900 | ENSBTAP00000044619 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (By similarity). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic [...] | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.901 |
GUCY1A1 | ENPP3 | ENSBTAP00000064987 | ENSBTAP00000026900 | Guanylate cyclase soluble subunit alpha-1. | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (By similarity). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic [...] | 0.902 |
GUCY1A1 | GUCY1B1 | ENSBTAP00000064987 | ENSBTAP00000005009 | Guanylate cyclase soluble subunit alpha-1. | Guanylate cyclase soluble subunit beta-1; Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | 0.996 |
GUCY1A1 | ITPA | ENSBTAP00000064987 | ENSBTAP00000072806 | Guanylate cyclase soluble subunit alpha-1. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.913 |
GUCY1A1 | LOC112449027 | ENSBTAP00000064987 | ENSBTAP00000009810 | Guanylate cyclase soluble subunit alpha-1. | Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | 0.970 |
GUCY1A1 | NOS1 | ENSBTAP00000064987 | ENSBTAP00000065649 | Guanylate cyclase soluble subunit alpha-1. | Nitric oxide synthase; Produces nitric oxide (NO). | 0.907 |
GUCY1A1 | NUDT2 | ENSBTAP00000064987 | ENSBTAP00000042493 | Guanylate cyclase soluble subunit alpha-1. | Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis. | 0.902 |
GUCY1A1 | PKLR | ENSBTAP00000064987 | ENSBTAP00000061000 | Guanylate cyclase soluble subunit alpha-1. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.904 |
GUCY1A1 | PKM | ENSBTAP00000064987 | ENSBTAP00000044619 | Guanylate cyclase soluble subunit alpha-1. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.904 |
GUCY1A1 | PRKG1 | ENSBTAP00000064987 | ENSBTAP00000030518 | Guanylate cyclase soluble subunit alpha-1. | cGMP-dependent protein kinase 1; Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-s [...] | 0.948 |
GUCY1A1 | PRKG2 | ENSBTAP00000064987 | ENSBTAP00000003877 | Guanylate cyclase soluble subunit alpha-1. | cGMP-dependent protein kinase. | 0.957 |
GUCY1B1 | ENPP3 | ENSBTAP00000005009 | ENSBTAP00000026900 | Guanylate cyclase soluble subunit beta-1; Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (By similarity). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic [...] | 0.907 |
GUCY1B1 | GUCY1A1 | ENSBTAP00000005009 | ENSBTAP00000064987 | Guanylate cyclase soluble subunit beta-1; Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | Guanylate cyclase soluble subunit alpha-1. | 0.996 |
GUCY1B1 | ITPA | ENSBTAP00000005009 | ENSBTAP00000072806 | Guanylate cyclase soluble subunit beta-1; Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. | 0.912 |